2010 Fiscal Year Final Research Report
Development of early diagnosis of malignant mesothelioma : Comprehensive analysis of secretory and membrane proteins
| Project/Area Number |
20590377
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
TSUJIMURA Tohru Hyogo College of Medicine, 医学部, 教授 (20227408)
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| Co-Investigator(Kenkyū-buntansha) |
TORII Ikuko 兵庫医科大学, 医学部, 講師 (70207661)
SATO Ayuko 兵庫医科大学, 医学部, 助教 (20419823)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 分子病理 / 中皮腫 |
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| Research Abstract |
We made monoclonal antibodies by using a malignant mesothelioma cell line as an immunogen, and obtained a clone of monoclonal antibody which reacts with a surface molecule of malignant mesothelioma, but not that of pulmonary adenocarcinoma. This clone showed strong immunoreactivity for malignant mesothelioma. In addition, we identified a cell adhesion molecule, which was expressed in malignant mesothelioma cells, but not reactive mesothelial cells, in pleural effusion. The clone of monoclonal antibody and the cell adhesion molecule may be useful for early diagnosis of malignant mesothelioma.
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