2010 Fiscal Year Final Research Report
Transcriptionaland translational regulation of peptide factors for the growth and differentiation of gastrointestinal epithelial cells
| Project/Area Number |
20590382
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | University of Fukui |
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Principal Investigator |
ITOH Hiroshi University of Fukui, 医学部, 教授 (80253847)
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| Co-Investigator(Kenkyū-buntansha) |
NAGANUMA Seiji 福井大学, 医学部, 助教 (50452123)
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| Co-Investigator(Renkei-kenkyūsha) |
KATAOKA Hiroaki 宮崎大学, 医学部, 教授 (10214321)
KITAMURA Naomi 東京工業大学, 生命理工学研究科, 教授 (80107424)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 分子 / 消化管粘膜上皮 |
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| Research Abstract |
MicroRNA (miRNA) expression pattern and target mRNAs of squamous cell carcinoma (SCC) are different from those of other organ's malignancies. MiR-205 might be a specific marker miRNA of both normal and malignant squamous epithelia, while miR-21 might be a putative oncogenic miRNA in SCC. In addition, several miRNAs including miR-200c and miR-27b are down-regulated by HGF stimulation. These miRNAs might play an important role for the translation of HGF downstream functional molecules.
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