2011 Fiscal Year Final Research Report
Mechanism underlying functional impairment of hematopoietic stem cell niches caused by oxidative stress at the site of xenobiotic interrelationship
| Project/Area Number |
20590388
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
HIRABAYASHI Yoko 国立医薬品食品衛生研究所, 安全性生物試験研究センター毒性部, 室長 (30291115)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Tohru 国立医薬品食品衛生研究所, 安全性生物試験研究センター, 客員研究員 (50100110)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 造血幹細胞 / 幹細胞ニッチ / 生体異物相互作用 / 細胞周期 / 酸化的ストレス |
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| Research Abstract |
The aims of this study were to focus on and analyze the hematopoietic regulatory system on the basis of three aspects, specifically focusing on the effects of reactive oxygen. The first aim was to analyze the maintenance system of stem cells during the dormancy period and the system regulating their self-renewal during the cell cycle. The second aim was to examine the developmental termination of the cell cycle of hematopoietic stem cells and the molecular mechanisms related to hematopoietic kinetic changes during the developmental stage. The third aim was to examine changes in the cell-cycle fraction during the senescent stage with stress accumulation. As a result, a functionally different regulatory system was found to exist during stem cell differentiation, and a different regulatory mechanism during hematopoietic development is supposed to be present.
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