2011 Fiscal Year Final Research Report
Approach to Molecular Development of the Drug that induces Mitotic Catastrophe in Cancer cells
| Project/Area Number |
20590391
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Hokkaido University |
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Principal Investigator |
TAKIMOTO Masato 北海道大学, 遺伝子病制御研究所, 准教授 (30179585)
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| Co-Investigator(Kenkyū-buntansha) |
OCHIYA Takahiro 国立がんセンター研究所, 分子細胞治療研究分野, 分野長 (60192530)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 分裂破局死 / D40 / がん / 細胞死 / 増殖抑制 / RNA干渉 / p53 |
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| Research Abstract |
Synthetic double-stranded RNA specific to D40 gene (D40 siRNA) human cancer cell lines. D40 siRNA caused a p53 independent cell death "Mitotic Catastrophe". Further D40 siRNA treatment to tumor-burden experimental animals induced inhibitions of the tumor growth. The molecular therapy targeting to D40 protein is encouraging in human cancer treatment in future.
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