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2010 Fiscal Year Final Research Report

Mechanism of rapamycin-resistant translation in mouse hepatocellular carcinoma cells

Research Project

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Project/Area Number 20590392
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionAsahikawa Medical College

Principal Investigator

OGAWA Katsuhiro  Asahikawa Medical College, 医学部, 名誉教授 (50045514)

Project Period (FY) 2008 – 2010
KeywordsIRES / 肝癌 / 蛋白合成
Research Abstract

Although protein translation is activated by the PI3K-Akt-mTOR pathway in mouse hepatocarcinogenesis, rapamycin, a mTOR inhibitor, shows the limited antitumor effect on hepatocellular carcinomas and no effect on hepatic adenomas despite the fact that the cap-dependent protein translation is inhibited by rapamycin. Under the condition with rapamycin treatment, HIF-1α can continue to be expressed by the internal ribosomal entry site (IRES) mechanism. Furthermore, the mechanism of tumor necrosis induced by rapamycin was not due to the direct action against hepatocellular carcinoma cells but rather due to the angiotoxic effect of rapamycin against the vasculature of hepatocellular carcinomas.

  • Research Products

    (12 results)

All 2011 2009 2008 2007 2006 2005 Other

All Journal Article (3 results) Presentation (7 results) Book (1 results) Remarks (1 results)

  • [Journal Article] 肝発癌過程2011

    • Author(s)
      小川勝洋
    • Journal Title

      病理と臨床 29

      Pages: 1-8

  • [Journal Article] Molecular pathology of early stage chemically-induced hepatocarcinogenesis.2009

    • Author(s)
      小川勝洋
    • Journal Title

      Pathol Int 59

      Pages: 605-622

  • [Journal Article] Hypoxia-independent overexpression of hypoxia-inducible factor 1α as an early change in mouse hepatocarcinognesis.2006

    • Author(s)
      Tanaka H, Yamamoto M, Hashimoto N, Miyakoshi M, Tamakawa S, Yoshie M, Tokusashi Y, Yokoyama K, Yaginuma Y, Ogawa K.
    • Journal Title

      Cancer Res 66

      Pages: 11263-11270

  • [Presentation] Rapamycin induces necrosis in mouse hepatocellular carcinomas by antiangiogenic activity, but also activates cap-independent translation of HIF-1α in hepatocellular carcinoma cells.2009

    • Author(s)
      Tanaka H,, Yamamoto M, Hashimoto N, Miyakoshi M, Tamakawa S, Yoshie M, Tokusashi Y, Yokoyama K, Yaginuma Y, Ogawa K.
    • Organizer
      American Association for Cancer Research Annual Meeting
    • Place of Presentation
      Denver, CO
    • Year and Date
      20090000
  • [Presentation] Rapamycin activates cap-independent translation of HIF-1α in hepatocellular carcinoma cells.2009

    • Author(s)
      Tanaka H, Yamamoto M, Miyakoshi M, Tamakawa S, Yaginuma Y, Ogawa K.
    • Organizer
      日本癌学会
    • Year and Date
      20090000
  • [Presentation] Angiotoxic effect of rapamycin in mouse HCC cells and rapamycin-resistant mechanism of HCC cells.2008

    • Author(s)
      Tanaka H, Yamamoto M, Miyakoshi M, Tamakawa S, Yoshie M, Tokusashi Y, Yaginuma Y, Ogawa K.
    • Organizer
      日本癌学会
    • Year and Date
      20080000
  • [Presentation] Rapamycin処理マウス肝癌細胞におけるIRES依存的HIF-1α蛋白翻訳の活性化2008

    • Author(s)
      田中宏樹、山本雅大、宮腰昌明、玉川進、吉江真澄、徳差良彦、柳沼裕二、小川勝洋
    • Organizer
      分子生物学会
    • Year and Date
      20080000
  • [Presentation] Reciprocal activation of PI3K/Akt signaling and HIF-1α in progression of mouse hepatocarcinogenesis.2007

    • Author(s)
      Tanaka H, Yamamoto M, Hashimoto N, Miyakoshi M, Tamakawa S, Yoshie M, Tokusashi Y, Yokoyama K, Yaginuma Y, Ogawa K.
    • Organizer
      American Association for Cancer Research Annual Meeting
    • Place of Presentation
      Los Angeles, CA
    • Year and Date
      20070000
  • [Presentation] Hypoxia-independent overexpression of hypoxia-inducible factor 1α as an early change in mouse hepatocarcinogenesis.2006

    • Author(s)
      Tanaka H, Yamamoto M, Hashimoto N, Miyakoshi M, Tamakawa S, Yoshie M, Tokusashi Y, Yokoyama K, Yaginuma Y, Ogawa K.
    • Organizer
      American Association for Cancer Research Annual Meeting
    • Place of Presentation
      Washington DC
    • Year and Date
      20060000
  • [Presentation] Expression of hypoxia-inducible factor 1α in the early step of hepatic carcinogenesis.2005

    • Author(s)
      Tanaka H, Yamamoto M, Hashimoto N, Miyakoshi M, Tamakawa S, Yoshie M, Tokusashi Y, Yokoyama K, Yaginuma Y, Ogawa K.
    • Organizer
      American Association for Cancer Research Annual Meeting
    • Place of Presentation
      Anaheim, CA
    • Year and Date
      20050000
  • [Book] 実験動物利用マニュアル(第一部疾患モデルの作製と利用 第2章がん第3節消化器系 第2項肝臓(2)誘発モデル)

    • Author(s)
      小川勝洋
    • Publisher
      エー・シー・アイ出版
  • [Remarks] ホームページ等

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Published: 2012-01-26   Modified: 2016-04-21  

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