2010 Fiscal Year Final Research Report
Morphological and molecular pathological study of mucin -depleted foci as the preneoplastic lesion for depressed flat type on colon carcinogenesis
| Project/Area Number |
20590405
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
YOSHIMI Naoki University of the Ryukyus, 医学研究科, 教授 (30166996)
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| Co-Investigator(Kenkyū-buntansha) |
MORIOKA Takamitsu 琉球大学, 医学研究科, 助教 (70253961)
SBNVSB Ijspopsj 琉球大学, 医学部附属病院, 助教 (30315478)
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| Project Period (FY) |
2008 – 2010
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| Keywords | colon carcinogenesis / preneoplatic lesion / mucin |
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| Research Abstract |
Mucin-depleted foci (MDF), formed by dysplastic crypts devoid of mucin production, have identified in the colon of carcinogen-treated rodents. MDF are correlated with colon carcinogenesis and seemed to serve as precancerous lesion of flat-depressed colorectal cancer (CRC). We have, therefore, searched for MDF in sporadic CRC patients in larger sample size to reveal the histological characteristics of human MDF. Methods : Colonic samples from 53 patients of sporadic CRC were stained with Alcian blue and examined the presence of MDF. In the same samples, we also examined the presence of ACF and noticed that some MDF have ACF-like appearance. We defined these lesions as "protruded MDF" and analyzed histological features of these colonic mucosal lesions (ACF, MDF and protruded MDF). Results : We found a total of 354, 41 and 19 colonic mucosal lesions with a mean multiplicity of 44, 38.9 and 66.9 crypts (ACF, MDF and protruded MDF, respectively). The density of MDF like lesions (MDF and protruded MDF) was 0.0082 lesions/cm^2. ACF from sporadic CRC patients were corresponding to hyperplastic or nondysplasic lesions. On the other hand, MDF and protruded MDF were corresponding to low grade of dysplasia. We also found that Paneth cell metaplasia and infiltration of inflammatory cells were specific feature of MDF like lesions. Conclusions : This is the first report that investigating density and histological features of MDF like lesions from sporadic CRC patients in large sample size. MDF and protruded MDF which having both MDF and ACF appearance were suggested to serve as more advanced preneoplastic lesions in human colorectal carcinogenesis.
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[Patent(Industrial Property Rights)] ナノ粒子の生成・吐出器具およびこれを用いるナノ粒子の放出方法2008
Inventor(s)
玉城喜章, 岩崎公典, 近藤義和, 波平宣敬, 吉見直己, 富田真理子, 屋我実
Industrial Property Rights Holder
玉城喜章, 岩崎公典, 近藤義和, 波平宣敬, 吉見直己, 富田真理子, 屋我実
Industrial Property Number
特願,2008-226321
Filing Date
2008-09-03
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