2010 Fiscal Year Final Research Report
ERK5 is a target for gene amplification at 17p11 and promotes cell growth in hepatocellular carcinoma by regulating mitotic entry.
| Project/Area Number |
20590408
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
YASUI Kohichiroh Kyoto Prefectural University of Medicine, 医学研究科, 准教授(寄附講座) (30323695)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肝細胞癌 / 遺伝子増幅 / ERK5 / MAPK7 |
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| Research Abstract |
Using high-density oligonucleotide microarrays, we investigated DNA copy-number aberrations in hepatocellular carcinomas and detected a novel amplification at 17p11. Our results suggest that the ERK5 gene is the target of 17p11 amplification and that the ERK5 promotes the growth of hepatocellular carcinoma cells by regulating mitotic entry.
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