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2010 Fiscal Year Final Research Report

Analysis of mechanisms involved in multifunction of tumor invasion factor emmprin

Research Project

  • PDF
Project/Area Number 20590415
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionFukuoka University

Principal Investigator

NABESHIMA Kazuki  Fukuoka University, 医学部, 教授 (40189189)

Co-Investigator(Kenkyū-buntansha) HAMASAKI Makoto  福岡大学, 医学部, 講師 (90412600)
AOKI Mikiko  福岡大学, 医学部, 助教 (80469379)
Co-Investigator(Renkei-kenkyūsha) KOSHIKAWA Naohiko  東京大学, 医科学研究所, 助教 (70334282)
Project Period (FY) 2008 – 2010
Keywords腫瘍 / マトリックス・メタロプロテアーゼ / 浸潤 / 転移
Research Abstract

To analyze the mechanisms that are responsible for multifunction of emmprin, a tumor invasion-promoting factor, we induced crosslink among cell surface molecules by using a crosslinker BS3. The molecules, which had been crosskinked to emmprin, were analyzed by means of mass spectrometer. Up to now, the analysis has narrowed down to about 10 candidate molecules. Their abilities to complex with emmprin and stimulate fibroblasts to produce MMPs are now under investigation.

  • Research Products

    (4 results)

All 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Synthetic emmprin peptides inhibit tumor cell-fibroblast interaction-stimulated upregulation of MMP-2 and tumor cell invasion

    • Author(s)
      Koga K, Aoki M, SameshimaT, Hamasaki M, Egawa N, Seiki M, Toole BP, Suzumiya J, Nabeshima K
    • Journal Title

      Int J Oncol, accepted

    • Peer Reviewed
  • [Journal Article] Synthetic emmprin peptides with chitobiose substitution stimulate MMP-2 production by fibroblasts

    • Author(s)
      Kawakami T, Sameshima T, Hojo H, Koga K, Nakahara Y, Toole BP, Suzumiya J, Okada Y, Iwasaki A, Nabeshima K
    • Journal Title

      BMC Cancer, under revision

    • Peer Reviewed
  • [Presentation] Emmprin is released as glycocalyceal bodies2009

    • Author(s)
      Aoki M, Nabeshima K, et al.
    • Organizer
      8th Pan-Pacific Connective Tissue Societies Symposium
    • Place of Presentation
      Shonan Village Center
    • Year and Date
      20090604-20090607
  • [Remarks] ホームページ等

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Published: 2012-01-26   Modified: 2016-04-21  

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