2010 Fiscal Year Final Research Report
Novel function of histamine in atherosclerotic artery
| Project/Area Number |
20590416
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
TANIMOTO Akihide University of Occupational and Environmental Health, Japan, 医歯学総合研究科, 教授 (10217151)
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| Co-Investigator(Kenkyū-buntansha) |
SASAGURI Yasuyuki 産業医科大学, 医学部, 教授 (60140646)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 動脈硬化 / ヒスタミン / ヒスタミンレセプター(HR) / ヒスチジン脱炭酸酵素 / HDC / apoE-KOマウス / HR / apoE-KOマウス / スカベンジャー受容体 / 炎症因子 |
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| Research Abstract |
The relation of histamine signaling in the arterial wall and atherogenesis was investigated using apoE-H1R-KO, apoE-H2R-KO and apoE-HDC-KO mice. The mice were fed by high cholesterol diet (1.25% cholesterol, 15% lard and 0.5% cholic acid) for 12 weeks, and pathological examination and expression of inflammation-related genes were evaluated in the aortas. Even the high cholesterol diet induced much higher hypercholesterolemia in apoE-H2R-KO and apoE-HDC-KO mice, the atherosclerotic lesion formation and expression of many inflammation-related genes were reduced in these KO mice than in apoE-KO mice. The histamine signaling mediated through H2 receptor would play a pivotal role in atherogenesis by regulating the inflammatory response in the vascular wall.
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[Journal Article] Histamine deficiency decreases atherosclerosis and inflammatory response in apoE-KO mice independently on serum cholesterol level.2011
Author(s)
Wang KY, Tanimoto A, Guo X, Yamada S, Shimajiri S, Murata Y, Ding Y, Tsutsui M, Kato S, Watanabe T, Ohtsu H, Hirano K, Kohno K, Sasaguri Y.
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Journal Title
Arterioscler Thromb Vasc Biol. in press
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[Journal Article] Histamine Regulation in Glucose and Lipid Metabolism via Histamine Receptors. Model for Nonalcoholic Steatohepatitis in Mice.2010
Author(s)
Wang KY, Tanimoto A, Yamada S, Guo X, Ding Y, Watanabe T, Watanabe T, Kohno K, Hirano KI, Tsukada H, Sasaguri Y.
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Journal Title
Am J Pathol. 177
Pages: 713-723
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