Mechanism of tumor promoting effect by mesenchymal progenitor cell

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590417
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
• Principal Investigator: ISHII Genichiro National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 臨床開発センター, 室長 (00270869)
• Co-Investigator(Kenkyū-buntansha): OCHIAI Atsushi 独立行政法人国立がん研究センター, 東病院臨床開発センター・臨床腫瘍病理部, 部長 (60183034)
• Project Period (FY): 2008 – 2010
• Keywords: 間葉系前駆細胞 / がん間質 / がん進展

Research Abstract

This study showed that vascular adventitial fibroblast (VAFs) and bone-marrow derived fibroblast contain mesenchymal progenitor cells. Moreover we clarified that VAFs enhanced tumor formation, although "immature status" of VAFs did not contribute to enhanced tumor formation.

Research Products

• [Journal Article] Dynamic molecular changes associated with epithelial-mesenchymal transition and subsequent mesenchymal-epithelial transition in the early phase of metastatic tumor formation. (2011)
  • Author(s): Aokage K, Ishii G, Ohtaki Y, Yamaguchi Y, Hishida T, Yoshida J, Nishimura M, Nagai K, Ochiai A
  • Journal Title: Int J Cancer. 128(7) Pages: 1585-95
• [Journal Article] A novel histopathological evaluation method predicting the outcome of non-small cell lung cancer treated by neoadjuvant therapy : the prognostic importance of the area of residual tumor. (2010)
  • Author(s): Yamane Y, Ishii G, Goto K, Kojima M, Nakao M, Shimada Y, Nishiwaki Y, Nagai K, Kohrogi H, Ochiai A
  • Journal Title: J Thorac Oncol. 5(1) Pages: 49-55
• [Journal Article] Histopathologic Features of the Tumor Budding in Adenocarcinoma of the Lung : Tumor Budding As an Index to Predict the Potential Aggressiveness. (2010)
  • Author(s): Yamaguchi Y, Ishii G, Kojima M, Yoh K, Otsuka H, Otaki Y, Aokage K, Yanagi S, Nagai K, Nishiwaki Y, Ochiai A
  • Journal Title: J Thorac Oncol. 5(9) Pages: 1361-8
• [Journal Article] Fibroblasts associated with cancer cells keep enhanced migration activity after separation from cancer cells : a novel character of tumor educated fibroblasts. (2010)
  • Author(s): Ishii G, Hashimoto H, Asada K, Ito T, Hoshino A, Fujii S, Kojima M, Kuwata T, Harigaya K, Nagai K, Ushijima T, Ochiai A
  • Journal Title: Int J Oncol. 37(2) Pages: 317-25
• [Journal Article] Stromal macrophage expressing CD204 is associated with tumor aggressiveness in lung adenocarcinoma. (2010)
  • Author(s): Ohtaki Y, Ishii G, Nagai K, Ashimine S, Kuwata T, Hishida T, Nishimura M, Yoshida J, Takeyoshi I, Ochiai A
  • Journal Title: J Thorac Oncol. 5(10) Pages: 1507-15
• [Journal Article] Prognostic significance of carbonic anhydrase IX expression by cancer-associated fibroblasts in lung adenocarcinoma. (2009)
  • Author(s): Nakao M, Ishii G, Nagai K, Kawase A, Kenmotsu H, Kon-No H, Hishida T, Nishimura M, Yoshida J, Ochiai A
  • Journal Title: Cancer. 115(12) Pages: 2732-43
• [Journal Article] Improvement of the breaking strength of wound by combined treatment with recombinant human G-CSF, recombinant human M-CSF, and a TGF-beta1 receptor kinase inhibitor in rat skin. (2008)
  • Author(s): Sugiyama K, Ishii G, Ochiai A, Esumi H
  • Journal Title: Cancer Sci. 99(5) Pages: 1021-8
• [Journal Article] Human vascular adventitial fibroblasts contain mesenchymal stem/progenitor cells. (2008)
  • Author(s): Hoshino A, Chiba H, Nagai K, Ishii G, Ochiai A
  • Journal Title: Biochem Biophys Res Commun 368 Pages: 305-310
• [Journal Article] Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma. (2008)
  • Author(s): Kawase A, Ishii G, Nagai K, Ito T, Nagano T, Murata Y, Hishida T, Nishimura M, Yoshida J, Suzuki K, Ochiai A
  • Journal Title: Int J Cancer. 123(5) Pages: 1053-9
• [Journal Article] CD105-positive cells in pulmonary arterial blood of adult human lung cancer patients include mesenchymal progenitors. (2008)
  • Author(s): Chiba H, Ishii G, Ito TK, Aoyagi K, Sasaki H, Nagai K, Ochiai A
  • Journal Title: Stem Cells. 26(10) Pages: 2523-30