Molecular study of anti-protective immune response upon malaria

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590421
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Parasitology (including Sanitary zoology)
• Research Institution: Gunma University
• Principal Investigator: SUZUE Kazutomo Gunma University, 大学院・医学系研究科, 講師 (00333485)
• Project Period (FY): 2008 – 2010
• Keywords: マラリア / 防御免疫 / 免疫記憶 / ワクチン / マウス

Research Abstract

We have observed the functional changes of parasite-nonspecific T cells upon infection with Plasmodium. In this study, we addressed about the mechanisms and its impact of functional changes of parasite-non-specific T cells. First we identified that the functional changes of T cells are distinguishable of the activation pathway of conventional T cells. Next we identified that functional changes of T cells are influenced with another immune responses such as protection against Listeria and DNFB-induced contact hypersensitivity reaction.

Research Products

• [Journal Article] A critical role for phagocytosis in resistance to malaria in iron-deficient mice. (2011)
  • Author(s): Matsuzaki-Moriya C, Tu L, Ishida H, Imai T, Suzue K, Hirai M, Tetsutani K, Hamano S, Shimokawa C, Hisaeda H.
  • Journal Title: Eur J Immunol. 41 Pages: 1365-75
  • Peer Reviewed
• [Journal Article] Requirement of SIRPα for protective immunity against Leishmania major. (2010)
  • Author(s): Morimoto N, Murata Y, Motegi SI, Suzue K, Saito Y, Okazawa H, Ohnishi H, Kotani T, Kusakari S, Ishikawa O, Matozaki T.
  • Journal Title: Biochem Biophys Res Commun. 22 Pages: 385-9
  • Peer Reviewed
• [Journal Article] Development of experimental cerebral malaria is independent of IL-23 and IL-17. (2010)
  • Author(s): Ishida H, Matsuzaki-Moriya C, Imai T, Yanagisawa K, Nojima Y, Suzue K, Hirai M, Iwakura Y, Yoshimura A, Hamano S, Shimokawa C, Hisaeda H.
  • Journal Title: Biochem Biophys Res Commun. 26 Pages: 790-5
  • Peer Reviewed
• [Journal Article] Critical role of dendritic cells in determining the Th1/Th2 balance upon Leishmania major infection. (2008)
  • Author(s): Suzue K, Kobayashi S, Takeuchi T, Suzuki M, Koyasu S.
  • Journal Title: Int.Immunol. 20 Pages: 337-43
  • Peer Reviewed
• [Presentation] Parasite non-specific T cells were suppressed upon malaria infection (2010)
  • Author(s): Suzue K, Udagawa M, Kitamura Y, Hisaeda H, Koyasu S, Suzuki M
  • Organizer: 14^<th> International congress of immunology
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2010-08-22
• [Presentation] マラリア感染で起こる原虫非特異的T細胞の機能修飾によってもたらされる影響 (2010)
  • Author(s): 鈴江一友、宇田川麻衣、北村裕太、久枝一、小安重夫、鈴木守
  • Organizer: 第79回日本寄生虫学会大会
  • Place of Presentation: 旭川市
  • Year and Date: 2010-05-20
• [Book] 動物モデル活用ハンドブック(感染症モデル)(秋山徹、河府和義編) (2011)
  • Author(s): 鈴江一友
  • Total Pages: 239-251
  • Publisher: 羊土社
• [Book] 人獣共通感染症(マラリア、喜田宏編) (2011)
  • Author(s): 鈴江一友、鈴木守
  • Total Pages: 423-430
  • Publisher: 医薬ジャーナル社
• [Book] カラーイラストで学ぶ集中講義 生理学(増殖因子をはじめとする各種サイトカインはどう作用するのか?、岡田隆夫編) (2008)
  • Author(s): 鈴江一友、鯉渕典之
  • Total Pages: 312-313
  • Publisher: メジカルビュー社
• [Book] 実験医学増刊 Vol.26 No.20 樹状細胞による免疫制御と臨床応用(リーシュマニア原虫と樹状細胞、稲葉 カヨ 編) (2008)
  • Author(s): 鈴江一友、小安重夫
  • Total Pages: 3273-78
  • Publisher: 羊土社