2010 Fiscal Year Final Research Report
Development of molecular adjuvants for design of malaria vaccines
| Project/Area Number |
20590425
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
ARAKAWA Takeshi University of the Ryukyus, 熱帯生物圏研究センター, 准教授 (50305190)
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| Co-Investigator(Kenkyū-buntansha) |
MIYATA Takeshi 琉球大学, 熱帯生物圏研究センター, ポスドク研究員 (20448591)
TAIRA Toki 琉球大学, 農学部, 准教授 (60315463)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUBOI Takafumi 愛媛大学, 無細胞生命科学工学研究センター, 教授 (00188616)
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| Project Period (FY) |
2008 – 2010
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| Keywords | マラリア / ワクチン / アジュバント / デリバリーシステム / ワクチンプラットフォーム |
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| Research Abstract |
We have developed a novel strategy to increase immune responses by creating genetic protein fusion complex composed of three physically linked molecular entities : (i) a vaccine antigen, (ii) an α-helical coiled-coil, and (iii) an antigen-presenting cell-targeting ligand. Vaccine efficacy of the tricomponent complex was evaluated using an ookinete surface protein of Plasmodium vivax and a merozoite surface protein of Plasmodium yoelii. Immunization of mice conferred substantial levels of P. vivax transmission blockade as well as protection from lethal P. yoelii infection in mice. This system, designated as the tricomponent immunopotentiating system (TIPS), onto which any recombinant antigens could be loaded, may be a promising strategy in devising subunit vaccines against malaria.
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[Journal Article] Adenovirus-vectored Plasmodium vivax ookinete surface protein, Pvs25, as a potential transmission-blocking vaccine.2011
Author(s)
Miyata T, Harakuni T, Sugawa H, Sattabongkot, J, Kato A, Tachibana M, Torii M, Tsuboi T, Arakawa T
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Journal Title
Vaccine 29
Pages: 2720-2726
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[Journal Article] Malaria ookinete surface protein-based vaccination via the intranasal route completely blocks parasite transmission both in passive and active vaccination regimes in a rodent malaria infection model.2009
Author(s)
Arakawa T, Tachibana M, Miyata T, Harakuni T, Kohama H, Matsumoto Y, Tsuji N, Hisaeda H, Stowers A, Torii M, Tsuboi T.
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Journal Title
Infect. Immun. 17
Pages: 5496-5500
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[Remarks] ホームページ等
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