2010 Fiscal Year Final Research Report
Protective immunity to malaria through cooperative regulation by innate immune cells
| Project/Area Number |
20590428
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Kyorin University |
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Principal Investigator |
KOBAYASHI Fumie Kyorin University, 医学部, 教授 (20118889)
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| Co-Investigator(Kenkyū-buntansha) |
NIIKURA Mamoru 杏林大学, 医学部, 助教 (30407019)
INOUE Shin-Ichi 杏林大学, 医学部, 助教 (20466030)
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| Project Period (FY) |
2008 – 2010
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| Keywords | マラリア / 防御免疫 / 自然免疫細胞 / 樹状細胞 / T細胞 |
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| Research Abstract |
We examined roles of innate immune cells such as dendritic cells (DC) and gδ T cells in immunity to malaria by using murine malaria models. We found that proliferation of conventional DC early in infection is necessary for eliminating malaria parasites in late phase of infection. Analyses of DC in TCRδ-deficient mice infected with malaria parasites suggested that γδ T cells might play a pivotal role for maturation and activation of DC.
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