2010 Fiscal Year Final Research Report
Detection of TNF-α release from mast cells stimulated with Toxoplasma gondii.
| Project/Area Number |
20590430
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Teikyo University |
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Principal Investigator |
UEDA Takane Teikyo University, 医学部, 助教 (80459312)
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| Co-Investigator(Kenkyū-buntansha) |
ONO Yasuo 帝京大学, 医学部, 教授 (10177272)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 免疫 / 原虫 |
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| Research Abstract |
Bone marrow derived mast cells (BMMCs) from mice were examined for TNF-α release by stimulating with Toxoplasma gondii tachyzoites. BMMC stimulated with live tachyzoites of T.g (RH) or crude extracts released TNF-α in culture supernatant. TNF-α gene expression was also enhanced after T.g stimuli. Activation of neutrophils were observed in the cells stimulated with BMMC primed with T.g compared to stimulation with BMMC.
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