2010 Fiscal Year Final Research Report

Analysis of regulatory mechanism of motility essential for Entamoeba encystation and excystation

Research Project

Project/Area Number	20590432
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Parasitology (including Sanitary zoology)
Research Institution	Jikei University School of Medicine
Principal Investigator	MAKIOKA Asao Jikei University School of Medicine, 医学部, 准教授 (90119850)
Project Period (FY)	2008 – 2010
Keywords	Entamoeba / 嚢子形成 / 脱嚢 / コフィリン / プロフィリン / アクチン細胞骨格
Research Abstract	The encystation and excystation of Entamoeba are important processes for formation of the infective form and establishment of the infection. The present study focused on an actin depolymerizing factor cofilin and profilin, which are essential for reorganization of actin cytoskeleton, and investigated their identification, gene cloning, phylogeny, preparation of recombinant proteins, localization and expression analysis and found different expression of each molecules.

(4 results)