2010 Fiscal Year Final Research Report
Characterization of parasite's molecules specifying host-parasite relationship
| Project/Area Number |
20590433
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
ISHIWATA Kenji 東京慈恵会医科大学, 医学部, 准教授 (00241307)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 蠕虫 / 腸管免疫 |
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| Research Abstract |
Based on my previous evidences that linkage of sialic acid to mucins associates with expulsion of an gastrointestinal nematode, Nippostrongylus brasiliensis, from mice, and that existence of a small amount of sialomucin at the establishment of the worms, I tried to characterize ligand molecules expressed on the worms which affect the establishment/expulsion, especially those of sialomucin. No directional characteristic of the worms towards sialomucin was detected. Characterization of ligands of sialomucin is still going on. Analyses of glycosylation of mucins by the lectin-array and the MALDI-TOF-MS supported previously reported results.
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[Journal Article] Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks2010
Author(s)
Takeshi Wada, Kenji Ishiwata, Haruhiko Koseki, Tomoyuki Ishikura, Tsukasa Ugajin, Naotsugu Ohnuma, Kazushige Obata, Ryosuke Ishikawa, Soichiro Yoshikawa, Kaori Mukai, Yohei Kawano, Yoshiyuki Minegishi, Hiroo Yokozeki, Naohiro Watanabe, and Hajime Karasuyama
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Journal Title
J. Clin. Invest
Volume: 120
Pages: 2867-2875
Peer Reviewed
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