2011 Fiscal Year Final Research Report
Analysis of iron-acquire receptor protein of Vibrio parahaemolyticus and development of specific growth inhibitor
| Project/Area Number |
20590444
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | University of the Ryukyus (2011)
Okayama University (2008-2010) |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2011
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| Keywords | 病原性 / モノクローナル抗体 / 受容体 |
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| Research Abstract |
Most microorganisms absolutely require iron to survive and grow. Vibrio parahaemolyticus produces siderophore, vibrioferrin(VF), under iron restriction conditions. Although VF is important for growth of V. parahaemolyticus, its role for the pathogenesis remains unknown. In this study, Drosophila melanogaster was used for a growth assay of V. parahaemolyticus deletion mutant which lacks VF producibility, as a infection model. These results indicated that iron acquisition by VF was very important for the growth in D. melanogaster, and affected its lethal activity.
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[Journal Article] The Vibrio parahaemolyticus pvuAl gene(formerly termed psuA) encodes a second ferric vibrioferrin receptor that requires tonB22011
Author(s)
Tanabe, T., Funahashi, T., Okajima, N., Nakao, H., Takeuchi, Y., Miyamoto, K., Tsujibo, H., and Yamamoto, S.
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Journal Title
FEMS Microbiol. Lett
Volume: 324(1)
Pages: 73-79
Peer Reviewed
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[Journal Article] Inactivation of Vibrio vulnificus hemolysin through mutation of the N-or C-terminus of the lectin-like domain2011
Author(s)
Miyoshi, S., Abe, Y., Senoh, M., Mizuno, T., Maehara, Y., and Nakao, H.
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Journal Title
Toxicon
Volume: 57(6)
Pages: 904-908
Peer Reviewed
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[Journal Article] Assimilation of metal ions bound to porphyrins or phrphyrin-peptides by Vibrio vulnificus2010
Author(s)
Miyoshi, S., Sasaki, T., Kaku, N., Inoue, T., Uozumi, N., Maehara, Y., and Nakao, H.
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Journal Title
Biocontrol Sci.
Volume: 15
Pages: 1-6
Peer Reviewed
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[Journal Article] Modulation of Vibrio mimicus hemolysin through limited proteolysis by an endogenous metalloprotease2009
Author(s)
Mizuno, T., Sultan, S. Z., Kaneko, Y., Yoshimura, T., Maehara, Y., Nakao, H., Tsuchiya, T., Shinoda, S., Miyoshi, S.
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Journal Title
FEBS Journal
Volume: 276
Pages: 825-834
Peer Reviewed
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