2010 Fiscal Year Final Research Report
Role of macrophage in Helicobacter pylori infection
| Project/Area Number |
20590445
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Okayama University |
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Principal Investigator |
YOKOTA Kenji Okayama University, 大学院・保健学研究科, 准教授 (00243460)
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| Co-Investigator(Kenkyū-buntansha) |
AYADA Kiyoshi 岡山大学, 大学院・医歯薬学総合研究科, 助教 (00379835)
OGUMA Kenji 岡山大学, 大学院・医歯薬学総合研究科, 教授 (00002262)
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| Project Period (FY) |
2008 – 2010
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| Keywords | Helicobacter pylori / 胃ガン / DEC205 / Th1 / 2 / HSP60 / 冠動脈疾患 |
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| Research Abstract |
Expression of DEC205, which is antigen uptake receptor on macrophage, was increased in H.pylori infected patients with early gastric cancer. However mRNA of DEC205 was also increased in the patient without gastric cancer. Expression of Th1 cytokines was detected in lymphocyte stimulated with HSP60 from patients with gastric cancer. HSP60 stimulation and its response in T helper CD4 may be available for diagnosis or prediction of gastric cancer caused by H.pylori infection. On the other hand, HSP60 antibody may be associated with cardiovascular disease (CVD) induced by H.pylori infection.
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Research Products
(31 results)
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[Journal Article] Regulation of cellular immunity prevents Helicobacter pylori-induced atherosclerosis.2009
Author(s)
Ayada K, Yokota K, Hirai K, Fujimoto K, Kobayashi K, Ogawa H, Hatanaka K, Hirohata S, Yoshino T, Shoenfeld Y, Matsuura E, Oguma K.
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Journal Title
Lupus. 18(13)
Pages: 1154-1168
Peer Reviewed
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[Journal Article] Helicobacter pylori eradication may induce de novo, but transient and mild, reflux esophagitis : Prospective endoscopic evaluation.2009
Author(s)
Take S, Mizuno M, Ishiki K, Nagahara Y, Yoshida T, Yokota K, Oguma K, Okada H, Yamamoto K.
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Journal Title
J Gastroenterol Hepatol. 24(1)
Pages: 107-113
Peer Reviewed
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