2010 Fiscal Year Final Research Report
Molecular mechanism of inflammatory reaction induced by Helicobacter pylori lipopolysaccharides with weak endotoxic activities
| Project/Area Number |
20590450
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
YOKOTA Shin-ichi Sapporo Medical University, 医学部, 准教授 (10325863)
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| Co-Investigator(Kenkyū-buntansha) |
FUJII Nobuhiro 札幌医科大学, 医学部, 教授 (90133719)
OKABAYASHI Tamaki 札幌医科大学, 医学部, 講師 (10359995)
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| Co-Investigator(Renkei-kenkyūsha) |
AMANO Ken-ichi 秋田大学, バイオサイエンス教育・研究センター, 准教授 (40113766)
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| Research Collaborator |
KONNO Mutsuko 札幌厚生病院, 小児科, 部長
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| Project Period (FY) |
2008 – 2010
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| Keywords | 細菌 / 免疫学 / 感染症 / 細胞内情報伝達 / 自然免疫 / 発癌 / 炎症 |
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| Research Abstract |
Helicobacter pylori lipopolysaccharide (LPS) shares extremely low endotoxic activity compared with typical gram-negative bacterial LPS. We found that H. pylori LPS upregulated TLR4 expression via TLR2 signaling in gastric epithelial cell lines, which express very low levels of TLR4. H. pylori LPS sensitized gastric epithelial cells to other bacterial LPS through TLR4 upregulation, and promoted gastric epithelial cell growth. These activities are suggested that H. pylori LPS is a pathogenic factor for carcinogenesis.
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