2010 Fiscal Year Final Research Report
Role of nitric oxide in gastroduodenal pathogenesis following Helicobacter pylori infection
| Project/Area Number |
20590455
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Kyorin University |
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Principal Investigator |
KAMIYA Shigeru Kyorin University, 医学部, 教授 (10177587)
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| Co-Investigator(Kenkyū-buntansha) |
OSAKI Takako 杏林大学, 医学部, 講師 (90255406)
HANAWA Tomoko 杏林大学, 医学部, 講師 (80255405)
KURATA Satoshi 杏林大学, 医学部, 助教 (00383670)
YONEZAWA Hideo 杏林大学, 医学部, 助教 (60453528)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ヘリコバクター・ピロリ / 一酸化窒素 / 感染 / 胃炎 |
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| Research Abstract |
To examine correlation between nitric oxide (NO) generation and Helicobacter pylori infection, in vitro experiment and in vivo experiment using Mongolian gerbil were performed. Nitrite was shown to indicate stronger bactericidal effect on H. pylori than nitrate. There was no significant difference in the number of H. pylori colonized between nitrate treated and untreated gerbils. Concentrations of nitrate and nitrite in plasma and gastric juice were significantly higher in nitrate-treated gerbils than those in untreated ones. Cystic dilatation score was significantly lower in nitrate-treated gerbils than that in untreated gerbils. These results suggest that uptake of nitrate-containing food might regulate inflammatory changes of gastric mucosa following H. pylori infection.
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