2010 Fiscal Year Final Research Report
Elucidation of the mechanism of virological synapse mediated HTLV-1 infection
| Project/Area Number |
20590468
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Virology
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
HIGUCHI Masaya Niigata University, 医歯学系, 准教授 (50334678)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 細胞 / 感染 / シグナル伝達 |
|---|
| Research Abstract |
HTLV-1 infection is established through the tight interaction between HTLV-1 infected cells and target cells, so called the virological synapse. In this study, we found that PDZ domain containing cell polarity proteins Dlg1 and MPP7 play a crucial role in the HTLV-1 cell-to-cell infection. We also found that a HTLV-1 receptor GLUT-1 functions through its interaction with PDZ domain containing proteins.
|
