2010 Fiscal Year Final Research Report
Pursuit of molecular mechanism and responsible factor for retroviral genome dimerization and recombination.
| Project/Area Number |
20590471
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Osaka University |
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Principal Investigator |
SAKURAGI Junichi Osaka University, 微生物病研究所, 助教 (90273705)
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| Project Period (FY) |
2008 – 2010
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| Keywords | HIV / RNA / 二量体化 / 組換え / パッケージング |
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| Research Abstract |
We developed the unique systems to analyze retroviral genome dimerization or recombination, and performed the experiment to pursue the nature of HIV genome RNA within virus particles. As a result, we suggested the reasonable evidence that genome dimerization directly controls the genome recombination. As this hypothesis has long been proposed but the direct evidence has not been shown, this data has a great significance. We also unveiled the precise relationship between virion maturation and viral genome maturation process. These results are expected to accelerate analyzing of virion maturation mechanism of HIV-1, which has been largely unclear.
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