2010 Fiscal Year Final Research Report
The effects of hepatocyte steatosis and adipocytokines on HCV replication
| Project/Area Number |
20590475
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2010
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| Keywords | C型肝炎ウイルス / アディポサイトカイン / インターフェロン |
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| Research Abstract |
Hepatitis C virus(HCV) is a health-care problem causing a spectrum of liver disease ranging from chronic hepatitis to liver cirrhosis and hepatocellular carcinoma. Anti-HCV treatments are based on a major antiviral cytokine, interferon(IFN). Obesity is reported to be an independent negative predictor of response to hepatitis C treatment. In the present study, we examined the influence of hepatocyte steatosis induced by free fatty acid on HCV replication and the action of adipocytokine(adiponectin, resistin, PAI-1) alone, or in combination with IFN, on HCV replication using the replicon system. Our results showed that hepatocyte steatosis and adipocytokines had no effect on HCV replication.
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