2010 Fiscal Year Final Research Report
Motility and intelligence of influenza virus
| Project/Area Number |
20590479
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Virology
|
|---|
| Research Institution | Kawasaki Medical School |
|---|
Principal Investigator |
SAKAI Tatsuya Kawasaki Medical School, 医学部, 助教 (00309543)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ITO Toshihiro 鳥取大学, 農学部, 教授 (00176348)
HIRABAYAHI Jun 産業技術総合研究所, 糖鎖工学センター, 副センター長 (40156691)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 感染防御 / ワクチン |
|---|
| Research Abstract |
In this research, I demonstrated that Influenza virus has motility and intelligence. Influenza virus moves on a cell surface by exchanging bindings between hemagglutinin and sialoglycan. Avian influenza virus tends not to move backward as an intelligent particle, since viral neuraminidase destroys sialoglycans along a track which the virus particle has moved before. I also demonstrated that virus motion pattern and intelligent level are modified by affinity of hemagglutinin to sialoglycan and enzymatic activity of neuraminidase.
|
Research Products
(8 results)
