Mechanism of memory CD8 T cell generation

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590486
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: Chiba University
• Principal Investigator: SAKAMOTO Akemi Chiba University, 大学院・医学研究院, 助教 (90359597)
• Co-Investigator(Kenkyū-buntansha): TOKUHISA Takesi 千葉大学, 大学院・医学研究院, 教授 (20134364) ; HATANO Masahiko 千葉大学, 大学院・医学研究院, 教授 (20208523) ; AROMA Masafumi 千葉大学, 大学院・医学研究院, 講師 (00202763) ; FUJIMURA Riza 千葉大学, バイオメディカル研究センター, 助教 (30376363)
• Project Period (FY): 2008 – 2010
• Keywords: 免疫学 / 記憶T細胞 / 遺伝子 / 発現制御 / サイトカイン

Research Abstract

Transcription factor Bcl6 expresses in memory CD8 T cells, but its function is not elucidated. In this study, we found that KLRG1 is one of the molecular target of Bcl6. KLRG1 is known as inhibitory signaling for cell proliferation. Regulation of KLRG1 by Bcl6 might be important for keeping the function of memory CD8 T cells.

Research Products

• [Journal Article] Bcl6 is required for the development of mouse CD4+ and CD8α+ dendritic cells. (2011)
  • Author(s): Ohtsuka, H., Sakamoto, A., Pan, J., Inage, S., Horigome, S., Ichii, H., Arima, M., Hatano, M., Okada, S., Tokuhisa, T.
  • Journal Title: J.Immunol. 186 Pages: 255-263
  • Peer Reviewed
• [Journal Article] CXCR4 expression on activated B cells is down-regulated by CD63 and IL-21. (2011)
  • Author(s): Yoshida, N., Kitayama, D., Arima, M., Sakamoto, A., Inamine, A., Takano, H., Hatano, M., Koike, T., Tokuhisa, T.
  • Journal Title: J.Immunol. 186 Pages: 2800-2808
  • Peer Reviewed
• [Journal Article] The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis. (2010)
  • Author(s): Miyauchi, Y., Ninomiya, K., Miyamoto, H., Sakamoto, A., Iwasaki, R., Hoshi, H., Miyamoto, K., Hao, W., Yoshida, S., Morioka, H., Chiba, K., Kato, S., Tokuhisa, T., Saitou, M., Toyama, Y., Suda, T., Miyamoto, T.
  • Journal Title: J Exp Med. 207 Pages: 751-762
  • Peer Reviewed
• [Journal Article] A role for Bcl6 in sequential class switch recombination to IgE in B cells stimulated with IL-4 and IL-21. (2008)
  • Author(s): Kitayama, D., Sakamoto, A., Arima, M., Hatano, M., Miyazaki, M., Tokuhisa, T.
  • Journal Title: Mol.Immunol. 45 Pages: 1337-1345
  • Peer Reviewed
• [Journal Article] A Lysosomal Protein Negatively Regulates Surface T Cell Antigen Receptor Expression by Promoting CD3ζ Degradation. (2008)
  • Author(s): Ouchida, R., Yamasaki , S., Hikida, M., Masuda, K., Kawamura, K., Wada, A., Mochizuki, S., Tagawa, M., Sakamoto, A., Hatano, M., Tokuhisa, T., Koseki, H., Saito, T., Kurosaki, T., Wang, J.
  • Journal Title: Immunity 29 Pages: 33-43
  • Peer Reviewed
• [Presentation] A Role of Bcl6 in the generation and maintenance of follicular helper T cells. (2010)
  • Author(s): Sakamoto A, Pan J, Kohno M, Arima M, Hatano M, Tokuhisa T.
  • Organizer: 14^<th> International congress of Immunology
  • Place of Presentation: 神戸
  • Year and Date: 20100822-20100827
• [Presentation] Roles of Bcl6 in memory T cell development. (2010)
  • Author(s): Sakamoto A.
  • Organizer: 免疫記憶シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2010-12-04
• [Presentation] Role of Bcl6 in the generation and maintenance of follicular helper T cells. (2009)
  • Author(s): Sakamoto A, Pan J, Mochiduki A, Kohno M, Arima M, Hatano M, Tokuhisa T.
  • Organizer: 第39回日本免疫学会
  • Place of Presentation: 大阪
  • Year and Date: 20091202-20091204
• [Presentation] Role of Bcl6 in the generation of follicular helper T cells. (2008)
  • Author(s): Sakamoto A, Arima M, Hatano M, Tokuhisa T.
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 京都
  • Year and Date: 20081201-20081203
• [Book] 改訂:培養細胞実験(10-4血液細胞 実験医学別冊ハンドブック)(黒木登志夫、許南浩編) (2009)
  • Author(s): 坂本明美、徳久剛史
  • Total Pages: 110-115
  • Publisher: 羊土社
• [Remarks] ホームページ等
  • URL: http://www.m.chiba-u.ac.jp/class/devgen/