2010 Fiscal Year Final Research Report
Physiological roles of signal transducers and modulators in the regulation of B cell functions.
| Project/Area Number |
20590492
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Keio University |
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Principal Investigator |
KOBAYASHI Takashi Keio University, 医学部, 准教授 (30380520)
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| Project Period (FY) |
2008 – 2010
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| Keywords | シグナル伝達 / B細胞 / 抗体 / アレルギー |
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| Research Abstract |
Physiological roles of signal transducers and modulators in B cells were investigated. It has been clarified that TRAF6, a signal transducer of CD40 and Toll-like receptor family, is necessary for an appropriate humoral immune response and the development of a certain B cell subset. On the other hand, SOCS1, a suppressor of cytokine signaling, regulates the susceptibility to IgE-dependent allergic responses in vivo by suppressing IL-4/STAT6 pathway and subsequent IgE production in B cells.
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[Journal Article] TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses.2009
Author(s)
Kobayashi T, Kim TS, Jacob A, Walsh MC, Kadono Y, Fuentes-Panana E, Yoshioka T, Yoshimura A, Yamamoto M, Kaisho T, Akira S, Monroe JG, Choi Y
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Journal Title
PLoS ONE. 4(3)
Pages: e4736
Peer Reviewed
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[Presentation] TRAF6 Is Required for Generation of the B-1a B Cell Compartment as well as T Cell-Dependent and-Independent Humoral Immune Responses.2009
Author(s)
Takashi Kobayashi, Anand Jacob, Tae Soo Kim, Miyuri Kawasumi, Akihiko Yoshimura, Masahiro Yamamoto, Tsuneyasu Kaisho, Shizuo Akira, Yongwon Choi
Organizer
The 1^<st> international Kishimoto foundation symposium, Immune Regulation : Present and Future
Place of Presentation
Osaka, Japan
Year and Date
2009-05-25
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[Remarks] ホームページ等
