2010 Fiscal Year Final Research Report
Analysis on the roles of PLCγ2 in generation and maintenance of immunological memory
| Project/Area Number |
20590497
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Kyoto University |
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Principal Investigator |
HIKIDA Masaki Kyoto University, 医学研究科, 教授 (60228715)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 免疫学 / 遺伝子 / 動物 / 病理学 / ゲノム |
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| Research Abstract |
In spite of previous researches, molecular basis for the development and survival of memory B cells remains largely unknown. In this study, we tried to clarify the roles of PLCγ2 on such molecular machinery. As the result, we found that PLCγ2 is playing a pivotal role in the formation of germinal center, where memory B cells are formed. It was also revealed that PLCγ2 is essential for the maintenance of the memory B cells.
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