2010 Fiscal Year Final Research Report
Role of zinc transporter in mast cell activation
| Project/Area Number |
20590498
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
NISHIDA Keigo The Institute of Physical and Chemical Research, サイトカイン制御研究グループ, 上級研究員 (80360618)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アレルギー / マスト細胞 / 亜鉛 / 亜鉛トランスポーター / サイトカイン / シグナル伝達 |
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| Research Abstract |
I am investigating the role of Zn of mast cells in allergy. I am analyzing in role of zinc transporters in mast cell-mediated allergic reactions. We found that a Zn transporter, Znt5/Slc30a5 is required for Fc epsilon RI-mediated cytokine production, but not degranulation. As a result, Znt5-/- mice had defects in mast cell-mediated delayed-type allergic reactions but not in the immediate-type reaction. Znt5 was required for Fc epsilon RI-induced translocation of PKC to the plasma membrane and the nuclear translocation of NF-kappa B. Thus, Zinc transporter Znt5 is selectively required for mast cell-mediated delayed-type allergic responses, and is a novel player in PKC signaling.
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[Journal Article] Crucial role for autophagy in degranulation of mast cells.2011
Author(s)
Ushio H, Ueno T, Kojima Y, Komatsu M, Tanaka S, Yamamoto A, Ichimura Y, Ezaki J, Nishida K, Komazawa-Sakon S, Niyonsaba F, Ishii T, Yanagawa T, Kominami E, Ogawa H, Okumura K, Nakano H.
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Journal Title
J Allergy Clin Immunol.
Pages: DOI:10.1016
Peer Reviewed
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[Journal Article] SHP2 mediates gp130-dependent cardiomyocyte hypertrophy via negative regulation of skeletal alpha-actin gene.2010
Author(s)
Nakaoka Y, Shioyama W, Kunimoto S, Arita Y, Higuchi K, Yamamoto K, Fujio Y, Nishida K, Kuroda T, Hirota H, Yamauchi-Takihara K, Hirano T, Komuro I, Mochizuki N
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Journal Title
J Mol Cell Cardiol. 49
Pages: 157-164
Peer Reviewed
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[Journal Article] Interaction of scaffolding adaptor protein Gab1 with tyrosine phosphatase SHP2 negatively regulates IGF-I-dependent myogenic differentiation via the ERK1/2 signaling pathway.2008
Author(s)
Koyama T, Nakaoka Y, Fujio Y, Hirota H, Nishida K, Sugiyama S, Okamoto K, Yamauchi-Takihara K, Yoshimura M, Mochizuki S, Hori M, Hirano T, Mochizuki N
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Journal Title
J Biol Chem. 283
Pages: 24234-2444
Peer Reviewed
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