2010 Fiscal Year Final Research Report
Molecular mechanisms of sublingual immunotherapy
| Project/Area Number |
20590502
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
HIROI Takachika Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 副参事研究員 (80228824)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 粘膜免疫 / 舌下免疫療法 / スギ花粉症 / アレルギー |
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| Research Abstract |
In this study, we comparatively examined the effect of SLIT on antigen-induced airway inflammation developed in bronchoalveolar and nasal cavities in mice. Massive infiltration of eosinophils as well as neutrophils into the bronchoalveolar cavity was induced by intratracheal OVA challenge. In the nasal cavity, eosinophil accumulation was occurred, though the number of neutrophils was not significantly changed, in response to nasal antigen challenge. These antigen-induced airway inflammatory responses, including increase in the number of eosinophils and/or neutrophils in the bronchoalveolar and nasal cavities were clearly suppressed by sublingual OVA administration. This animal model displaying differential inflammatory responses in the bronchoalveolar and nasal cavities may be useful to elucidate the efficacy and mechanisms of SLIT against various allergic diseases.
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[Journal Article] T. T-box 21 transcription factor is responsible for distorted TH2 differentiation in human peripheral CD4+ T cells2009
Author(s)
Kaminuma O., Kitamura F., Miyatake S., Yamaoka K., Miyoshi H, Inokuma S, Tatsumi H, Nemoto S, Kitamura N, Mori A, Hiroi
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Journal Title
J Allergy Clin Immunol 123
Pages: 813-823
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[Presentation] Differential contribution of CCR4 expressed on Th2 and Th17 cells to antigen-induced airway inflammation2010
Author(s)
Kaminuma O, Kitamura F, Motoi Y, Suzuki K, Katayama K, Hiroi T, Ohtomo T, Mori A, Nagakubo D, Hieshima K, Yoshie O.
Organizer
14th International Congress of Immunology
Place of Presentation
Kobe
Year and Date
2010-08-24
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[Presentation] Hyperexpression of T-bet is responsible for incomplete human Th2 differentiation2009
Author(s)
Kaminuma O., Kitamura N., Mori A., Tatsumi H., Nemoto S., Inokuma S., Miyoshi H., Kitamura F., Miyatake S., Yamaoka K., Hiroi T.
Organizer
第39回日本免疫学会総会
Place of Presentation
大阪
Year and Date
2009-12-02
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