2010 Fiscal Year Final Research Report
Development of pharmacometric system for anti-atherogenic effect based on vascular endothelial function
| Project/Area Number |
20590542
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
YAMAKAWA Ken University of the Ryukyus, 大学院・医学研究科, 講師 (00363664)
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| Co-Investigator(Kenkyū-buntansha) |
YASU Takanori 琉球大学, 大学院・医学研究科, 准教授 (40265278)
SHIMABUKURO Michio 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 特任教授 (60271144)
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| Co-Investigator(Renkei-kenkyūsha) |
UEDA Shinichiro 琉球大学, 大学院・医学研究科, 教授 (80285105)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 臨床薬理学 |
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| Research Abstract |
Vascular endothelial function is not only a predictor of future cardio vascular events, but an useful therapeutic marker. We investigated pharmacometric analysis on vascular endothelial function for several cardiovascular drugs and their therapeutic mechanisms.
We adopted free fatty acids (FFA) loading model of human to investigate vascular and metabolic pathophysiology of visceral fat obesity. Elevated FFA caused endothelial dysfunction, increased sticking strength of leukocytes and insulin resistance partly via leukocyte renin-angiotensin system. Leukocyte renin-angiotensin system activity could be a marker of vascular endothelial dysfunction which accompanies visceral fat obesity.
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[Presentation] 進行性糖尿病性腎症患者を対象とした医師主導ランダム化臨床試験OKINAWA study実施における患者登録上の問題点2010
Author(s)
植田育子, 佐々木麻衣, 幸喜毅, 山川研, 城間勲, 屋良朝博, 長澤慶尚, 湧上民雄, 砂川優, 山里将浩, 平良伸一郎, 池間朋己, 神谷乗史, 小宮一郎, 益崎裕章, 植田真一郎
Organizer
第53回日本糖尿病学会年次学術集会
Place of Presentation
岡山市
Year and Date
2010-05-29
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[Remarks] ホームページ等
