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2010 Fiscal Year Final Research Report

Role of intestinal macrophages in the pathogenesis of intestinal lesions induced by non-steroidal anti-inflammatory drugs.

Research Project

  • PDF
Project/Area Number 20590550
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionKyoto Pharmaceutical University

Principal Investigator

KATO Shinichi  Kyoto Pharmaceutical University, 薬学部, 准教授 (90281500)

Project Period (FY) 2008 – 2010
Keywords非ステロイド性抗炎症薬(NSAID) / マクロファージ / 消化管傷害 / α7ニコチン性アセチルコリン受容体 / 内皮型NO合成酵素 / 一酸化窒素(NO)
Research Abstract

In the present study, we investigated the role intestinal macrophages in the pathogenesis of gastrointestinal diseases.
1. The activation of α7 nicotinic acetylcholine receptor (α7nAChR) suppresses the severity of intestinal lesions induced by non-steroidal anti-inflammatory drugs (NSAID).
2. Dopamine D2 receptor antagonists significantly prevent NSAID-induced intestinal lesions through activation ofα7nAChR.
3. The aggravation of NSAID-induced gastric damage during arthritis is attributable to the upregulation of iNOS and eNOS.
4. Lansoprazole, a proton pump inhibitor, protects NSAID-induced intestinal lesions through induction of heme oxygenase (HO)-1.
5. Macrophages play a beneficial role in the healing of chronic gastric ulcers mediated by increase in neovascularization through upregulation of cyclooxygenase (COX)-2 and vascular endothelial growth factor (VEGF).

  • Research Products

    (8 results)

All 2011 2010 2009

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (3 results)

  • [Journal Article] Activation of α7 nicotinic acetylcholine receptors ameliorates indomethacin-induced small intestinal ulceration in mice2011

    • Author(s)
      Kawahara R, Yasuda M, Hashimura H, Amagase K, Kato S, Takeuchi K
    • Journal Title

      European Journal of Pharmacology 650

      Pages: 248-261

    • Peer Reviewed
  • [Journal Article] Roles of COX inhibition in pathogenesis of NSAID-induced small intestinal damage2010

    • Author(s)
      Takeuchi K, Tanaka A, Kato S, Amagase K, Satoh H
    • Journal Title

      Clinica Chimica Acta 411

      Pages: 459-466

    • Peer Reviewed
  • [Journal Article] Prevention by lansoprazole, a proton pump inhibitor, of indomethacin-induced small intestinal ulceration in rats.2010

    • Author(s)
      Yoda Y, Amagase K, Kato S, Tokioka S, Murano M, Kakimoto K, Nishio H, Umegaki E, Takeuchi K, Higuchi K.
    • Journal Title

      Journal of Physiology and Pharmacology 61

      Pages: 287-294

    • Peer Reviewed
  • [Journal Article] Role of endothelial nitric oxide synthase in aggravation of indomethacin-induced gastric damage in adjuvant arthritic rats.2009

    • Author(s)
      Kato S, Ohkawa F, Ito Y, Takeuchi K.
    • Journal Title

      Journal of Physiology and Pharmacology 60

      Pages: 147-155

    • Peer Reviewed
  • [Journal Article] Aggravation of cold-restraint stress-induced gastric lesions in adjuvant arthritic rats : pathogenic role of inducible and endothelial nitric oxide.2009

    • Author(s)
      Kato S, Kawahara R, Yasuda M, Amagase K, Takeuchi K.
    • Journal Title

      Journal of Pharmacological Sciences 111

      Pages: 244-252

    • Peer Reviewed
  • [Presentation] α7ニコチン受容体活性化によるインドメタシン誘起小腸傷害の抑制2011

    • Author(s)
      河原良治、安田仁、橋村寛、天ヶ瀬紀久子、加藤伸一、竹内孝治
    • Organizer
      第7回日本消化管学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2011-02-18
  • [Presentation] Different mechanisms of effective PPIs or H2-blockers for prevention of NSAID-induced small intestinal damage.2010

    • Author(s)
      Yoda Y, Amagase K, Kato S, Tokioka S, Murano M, Kakimoto K, Takeuchi K, Higuchi K.
    • Organizer
      米国消化器病学会
    • Place of Presentation
      米国ニューオリンズ
    • Year and Date
      2010-05-03
  • [Presentation] α7ニコチン受容体活性化によるインドメタシン誘起小腸傷害の抑制効果2010

    • Author(s)
      河原良治、安田仁、天ヶ瀬紀久子、加藤伸一、竹内孝治
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-18

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Published: 2012-01-26   Modified: 2016-04-21  

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