2010 Fiscal Year Final Research Report
The role of micro RNA and methylated gene in multistep genesis and prognosis of multiple myeloma
| Project/Area Number |
20590556
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Gunma University |
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Principal Investigator |
HANDA Hiroshi Gunma University, 医学部, 講師 (90282409)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Hirokazu 群馬大学, 医学部, 教授 (40166260)
OGAWARA Hatsue 群馬大学, 医学部, 教授 (60134293)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 骨髄腫 / 多段階発癌 / メチル化遺伝子 / microRNA |
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| Research Abstract |
We detected methylated WWOX promoter in myeloma cell lines, myeloma patients but not in MGUS patients. The aberrant transcript of WWOX mRNA was detected in myeloma patients, MGUS and cell lines. The expression level of micro-RNA miR15a 15b, 16 were very low or lacked in purified plasma cells in some patients. MiR 15a, 15b, 16 levels were lower in plasma cells of MM than those of MGUS. On the contrary, Dnmts and Mcl-1 levels were higher in plasma cells of MM than those of MGUS.
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