2010 Fiscal Year Final Research Report
Role of Notch in the pathophysiology of leukemia stem cells and drug sensitivity tests for Notch inhibitors
| Project/Area Number |
20590557
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TOHDA Shuji Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 准教授 (80251510)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 臨床血液学 / 白血病 / 幹細胞 / Notch / 分子標的治療 |
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| Research Abstract |
In order to treat leukemia effectively, we have to understand the pathophysiology of leukemia stem cells. Notch signaling is important for the regulation of self-renewal of leukemia stem cells. We found the molecular mechanism how the Notch ligand stimulation activates the Notch signaling and how it leads to cell growth. Moreover, we found that gamma-secretase inhibitors, which inhibit Notch signaling, suppress the growth of leukemia cells. We developed the methods to predict its effects.
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[Journal Article] Negative feedback regulation of colitogenic CD4+ T cells by increased granulopoiesis.2008
Author(s)
Nemoto Y, Kanai T, Tohda S, Totsuka T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Fukuda T, Miura O, Yagita H, Watanabe M.
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Journal Title
Inflamm Bowel Dis 14
Pages: 1491-1503
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