2010 Fiscal Year Final Research Report
Novel method of measuring activities of enzymes involved in lipid metabolism
| Project/Area Number |
20590560
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
KOBAYASHI Junji Kanazawa University, 医学系研究科, 特任教授 (60302577)
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| Co-Investigator(Kenkyū-buntansha) |
NOHARA Atsushi 金沢大学, 医学系研究科, 特任助教 (50313648)
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| Project Period (FY) |
2008 – 2010
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| Keywords | LPL / HTGL / ANGPTL3 |
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| Research Abstract |
We have established a simple and reliable system for measuring LPL and HTGL activities in post-heparin plasma and investigated clinical significance of measuring those activities. LPL activities showed inverse relations with TG, RLP-TG and sdLDL and positive relations with HDL-C but had no relation with ANGPTL3. HTGL activities showed no relation with TG, RLP-TG and sdLDL but had inverse relations with HDL-C and ANGPTL3. In vitro experiment showed that ANGPTL3 did not inhibit HTGL activities at all, suggesting unidentified molecule may regulate ANGPTL3 and HTGL each other in opposite directions.
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Research Products
(25 results)
