2010 Fiscal Year Final Research Report
Pathogensis of H. heilmannii-related gastric mucosal legions
| Project/Area Number |
20590564
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Shinshu University |
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Principal Investigator |
OTA Hiroyoshi Shinshu University, 医学部, 教授 (50273107)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Motohiro 信州大学, 医学系研究科, 講師 (00362137)
KAWAKAMI Yoshiyuki 信州大学, 医学部, 教授 (90283275)
SANO Kenji 信州大学, 医学部附属病院, 講師 (50205994)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ヘリコバクター・ハイルマニ / Helicobacter heilmannii / MALTリンパ腫 |
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| Research Abstract |
(1) Chronic gastritis and MALT lymphoma developed in the H. heilmannii-infected BALB/c mice. HEV-like vessels expressing GlcNAc6ST-1-mediated L-selectin ligand carbohydrate and MAdCAM-1 may play a crucial role in the pathogenesis of H. heilmannii-induced chronic gastritis and MALT lymphoma. (2) In culturing H. felis strains, the optimal condition for obtaining cells with the largest colony sizes or for obtaining the highest percentage of spiral forms were demonstrated. (3) Taxonomic analysis of clinically isolated H. heimannii strains disclosed that H. heilmannii SH6 represents a novel strain and should constitute a novel taxon in the phylogenetic trees.
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[Journal Article] Helicobacter heilmannii" can induce gastric lymphoid follicles in mice via a Peyer' s Patch independent pathway2010
Author(s)
Nobutani K, Yoshida M, Nishiumi S, Nishitani Y, Takagawa T, Tanaka H, Yamamoto K, Mimura T, Bensleiman Y, Ota Takahashi S, Matsui H, Nakamura M, Azuma T
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Journal Title
FEMS Immunol Med Microbiol 60
Pages: 156-164
Peer Reviewed
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[Journal Article] Japanese Society for Helicobacter Research.2010
Author(s)
Asaka M, Kato M, Takahashi S, Fukuda Y, Sugiyama T, Ota H, Uemura N, Murakami K, Satoh K, Sugano K
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Journal Title
Guidelines for the management of Helicobacter pylori infection in Japan : 2009 revised edition, Helicobacter 15
Pages: 1-20
Peer Reviewed
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[Journal Article] 日本ヘリコバクター学会ガイドライン作成委員会2009
Author(s)
浅香正博, 菅野健太郎, 高橋信一, 福田能啓, 杉山敏郎, 太田浩良, 上村直実, 村上和成, 佐藤貴一, 加藤元嗣
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Journal Title
日本ヘリコバクター学会"H.pylori感染の診断と治療のガイドライン"2009改訂版, 日本ヘリコバクター学会誌 10巻
Pages: 104-128
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