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2010 Fiscal Year Self-evaluation Report

Development of tumor diagnosis method using cancer/testis antigens.

Research Project

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Project/Area Number 20590571
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionOkayama University

Principal Investigator

ONO Toshiro  Okayama University, 自然生命科学研究支援センター, 准教授 (50185641)

Project Period (FY) 2008 – 2011
Keywordsがん・精巣抗原 / 抗体 / SEREX / 腫瘍マーカー
Research Abstract

精度の高いがんの検査・診断のためには、標的となるがん抗原、遺伝子の同定が必要となる。このためには種々のがんに発現するが正常組織では精巣に限局しているがん・精巣(CT)抗原が最も適している。われわれがすでに同定したOY-TES-1を始め数種類のCT抗原及び新たに同定する抗原と組み合わせることにより、広範囲ながん種に対して精度の高い新規のがんの検査・診断法を開発することを目的とする。

  • Research Products

    (14 results)

All 2011 2010 2009 2008 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (7 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Isolation and characterization of human lung cancer antigens by serological screening with autologous antibodies.2011

    • Author(s)
      T. Hanafusa, A.M. Ali Eldib, K. Kitaoka, Y. Ohue, E. Nakayama, T. Ono
    • Journal Title

      Cancer Letters 301

      Pages: 57-62

    • Peer Reviewed
  • [Journal Article] Targeting KRAS mutation-bearing lung cancer in vivo by pulmonary surfactant-adenovirus-mediated gene transfer.2010

    • Author(s)
      T. Fukazawa, Y. Maeda, J. Matsuoka, T. Ono(12名、4番目)
    • Journal Title

      Anticancer Research 30

      Pages: 4925-4935

    • Peer Reviewed
  • [Journal Article] Identification of CCDC62-2 as a novel cancer/testis antigen and its immunogenicity.2009

    • Author(s)
      S. Domae, Y. Nakamura, Y. Nakamura(17名、17番目)
    • Journal Title

      International Journal of Cancer 124

      Pages: 2347-2352

    • Peer Reviewed
  • [Journal Article] Identification of a CD4 T-cell epitope in the rejection antigen from BALB/c radiation-induced leukemia RL♂1.2008

    • Author(s)
      S. Kaya, A. Uenaka, S. Sto, T. Ono, T. Aji , E. Nakayama
    • Journal Title

      Cancer Science 99

      Pages: 1141-1147

    • Peer Reviewed
  • [Presentation] Isolation and characterization of human lung cancer antigens by serological screening with autologous antibodies.2010

    • Author(s)
      T.Hanafusa, K.Kitaoka, Y.Ohue, E.Nakayama, T.Ono
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-24
  • [Presentation] Targeting KRAS lung cancer in vivo by pulmonary surfactant-mediated gene transfer.2010

    • Author(s)
      T. Fukazawa, J. Matsuoka, T.Ono(9名、3番目)
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-24
  • [Presentation] SEREX法による肺腺癌抗原の同定と発現解析2010

    • Author(s)
      花房直志、北岡賢太、大植祥弘、中山睿一、小野俊朗
    • Organizer
      第14回日本がん免疫学会総会
    • Place of Presentation
      熊本市
    • Year and Date
      2010-07-22
  • [Presentation] Simultaneous expression of multiple splice variants of PCDH11X/Y in tumor cells.2009

    • Author(s)
      T.Hanafusa, T.Ono, E.Nakayama
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-10-02
  • [Presentation] Humoral immune response of cancer patients against new SEREX-defined antigen, CCDC62-2.2008

    • Author(s)
      S.Domae, T.Ono(8名、2番目)
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-10-29
  • [Presentation] SEREX法により同定したCCDC62-2に対する癌患者の液性免疫応答2008

    • Author(s)
      銅前昇平、小野俊朗(7名、2番目)
    • Organizer
      第12回基盤的癌免疫研究会総会
    • Place of Presentation
      さいたま市
    • Year and Date
      2008-07-02
  • [Presentation] Identification of a CD4 T-cell epitope on tumor rejection antigen RLakt in BALB/c radiation-leukemia RL male 1.2008

    • Author(s)
      K. Savas、上中明子(6名、4番目)
    • Organizer
      第12回基盤的癌免疫研究会総会
    • Place of Presentation
      さいたま市
    • Year and Date
      2008-07-02
  • [Patent(Industrial Property Rights)] 癌診断キットおよび癌診断方法2010

    • Inventor(s)
      小野俊朗、中山睿一
    • Industrial Property Rights Holder
      国立大学法人岡山大学
    • Industrial Property Number
      特許、特願2009-532105
    • Acquisition Date
      2010-03-10
  • [Patent(Industrial Property Rights)] 癌診断方法および癌診断キット2009

    • Inventor(s)
      小野俊朗、中山睿一
    • Industrial Property Rights Holder
      岡山大学
    • Industrial Property Number
      特許,特願2006-240787
    • Filing Date
      2009-07-14
  • [Patent(Industrial Property Rights)] Cancer Diagnostic Kit and Cancer Diagnostic Method

    • Inventor(s)
      小野俊朗, 中山睿一
    • Industrial Property Rights Holder
      National University Corporation Okayama University
    • Industrial Property Number
      Patent,08791311.7(EU),12/677,755(US),200880106505.9(CN)

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Published: 2012-02-13   Modified: 2016-04-21  

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