2011 Fiscal Year Final Research Report
Development of tumor diagnosis method using cancer/testis antigens.
| Project/Area Number |
20590571
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Okayama University |
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Principal Investigator |
ONO Toshiro 岡山大学, 自然生命科学研究支援センター, 准教授 (50185641)
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| Co-Investigator(Kenkyū-buntansha) |
HANAFUSA Tadashi 岡山大学, 自然生命科学研究支援センター, 助教 (00228511)
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| Co-Investigator(Renkei-kenkyūsha) |
UENAKA Akiko 岡山大学,川崎医療福祉大学, 医学部, 客員研究員,研究員 (50273967)
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| Project Period (FY) |
2008 – 2011
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| Keywords | がん・精巣抗原 / SEREX / 抗体 / 抗原 / ELISA / 腫瘍マーカー / リアルタイム / RT-PCR |
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| Research Abstract |
Cancer/testis(CT) antigens are expressed in normal germ cell line tissues and various cancers. They are considered promising target molecules for immunotherapy for patients with various cancers. We performed serological identification of antigens by recombinant expression cloning to identify CT antigens. The humoral immune response of cancer patients against the newly defined CT antigens was confirmed. This study indicated that the newly defined CT antigens facilitates their use as diagnostic reagents and establishes a testing and diagnostic method effective to cancers.
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