2010 Fiscal Year Final Research Report
Physiological role of 11-dehydrothromboxane B2 : parameter of platelet activity and aspirin resistance
| Project/Area Number |
20590573
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Okayama University |
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Principal Investigator |
MATSUURA Eiji Okayama University, 大学院・医歯薬学総合研究科, 教授 (20181688)
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| Co-Investigator(Kenkyū-buntansha) |
NISHII Nobuhiro 岡山大学, 病院, 助教 (50537214)
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| Project Period (FY) |
2008 – 2010
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| Keywords | トロンボキサンB2 / 血小板機能 / 疾患モデルマウス / アスピリン抵抗性 / 動脈硬化 / 酸化LDL |
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| Research Abstract |
Aspirin prevents platelet aggregation by irreversible acetylation of cyclooxygenase. We evaluated the usefulness of an enzyme-linked immunosorbent assay (ELISA) to determine levels of 11-dehydrothromboxane B2 in urine, which aids in the detection of aspirin effect post ingestion. In low-density lipoprotein receptor-deficient mice fed with a high fat diet and received aspirin, urinary 11-dehydrothromboxane B2 (11-dhTXB2) tended to decrease and atherosclerotic plaque area significantly decreased.
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Research Products
(9 results)
