2010 Fiscal Year Final Research Report
The molecules related with HTLV-1 infection and the identification of the risk factors for ATL.
| Project/Area Number |
20590581
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | University of Miyazaki |
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Principal Investigator |
NOMURA Hajime University of Miyazaki, 医学部, 助教 (80253839)
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| Co-Investigator(Kenkyū-buntansha) |
OKAYAMA Akihiko 宮崎大学, 医学部, 教授 (70204047)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ウイルス / 感染症 / 生体分子 |
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| Research Abstract |
The expression of HTLV-1 infection-related molecules (TSLC1, HBZ) in the clinical samples were examined. The solubilized form of TSLC1 and anti-HBZ antibody were definitely not detected in the samples of career patients. The analysis of provirus value in career patients demonstrated that clonal increase of cells carried deleted form of provirus were detected. The evaluation of risk factors concerning pathogenic mechanism of ATL would be performed with the new molecular information obtained.
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Research Products
(15 results)
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[Journal Article] Defective human T-lymphotropic virus type 1 provirus in asymptomatic carriers.2011
Author(s)
Takenouchi H, Umeki K, Sasaki D, Yamamoto I, Nomura H, Takajo I, Ueno S, Umekita K, Kamihira S, Morishita K, Okayama A.
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Journal Title
Int J Cancer. 128(6)
Pages: 1335-1343
Peer Reviewed
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[Journal Article] Intraand inter-laboratory variability in human T-cell leukemia virus type-1 proviral load quantification using real-time polymerase chain reaction assays : A multi-center study.2010
Author(s)
Kamihira S, Yamano Y, Iwanaga M, Sasaki D, Satake M, Okayama A, Umeki K, Kubota R, Izumo S, Yamaguchi K, Watanabe T.
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Journal Title
Cancer Science 101(11)
Pages: 2361-2367
Peer Reviewed
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[Presentation] HTLV-1キャリアにみられる欠損プロウイルスの多様性2009
Author(s)
高城一郎, 山本成郎, 梅木一美, 久保和義, 宮内俊一, 梅北邦彦, 上野史朗, 甲斐泰文, 長友安弘, 岡山昭彦
Organizer
第83回日本感染症学会総会・学術講演会
Place of Presentation
東京都新宿区,京王プラザホテル
Year and Date
2009-04-23
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[Remarks] ホームページ等
