2010 Fiscal Year Final Research Report
Study on the kinetics of soluble fibrin in blood and the utility of SF measurement in thrombosis.
| Project/Area Number |
20590583
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
IEKO Masahiro Health Sciences University of Hokkaido, 歯学部, 教授 (50250436)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 臨床検査医学 / 凝固線溶学 |
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| Research Abstract |
Various complexes of soluble fibrin (SF) are present in blood of patients with thrombosis. We investigated which in various complexes of SF increase immediately prior to the formation of thrombus, and whether the complex is a predictive factor for thrombosis. In patients with thrombotic tendency and with acute myocardial infarction, plasma FMC was significantly elevated in the early stage of thrombosis. Our results suggested that the thrombus formation in a small blood vessel can be reflected on FMC level. The determination of SF in the sample treated with 0.20μm or 0.45μm filter showed that the large～intermediate molecule of SF complexes increased in the early stage samples. When western blot analysis using monoclonal anti-fibrin monomer antibody, F405, after the isoelectric focusing electrophoresis, SF of various molecular weight were detected within the wide range (pH5～10 area) in early stage samples, suggesting the variety in blood kinetic of SF complexes in early stage of thrombus formation.
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[Journal Article] The effects of phosphatidylserine-dependent antiprothrombin antibody on thrombin generation.2009
Author(s)
Sakai Y, Atsumi T, Ieko M, Amengual O, Furukawa S, Furusaki A, Bohgaki M, Kataoka H, Horita T, Yasuda S, Koike T
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Journal Title
Arthritis Rheum 60
Pages: 2457-2467
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[Remarks] ホームページ等
