2010 Fiscal Year Final Research Report
Studies on the role of endogenous digitalis in electrolytes and blood pressure regulation
| Project/Area Number |
20590589
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kansai Medical University |
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Principal Investigator |
TAKAHASHI Hakuo Kansai Medical University, 医学部, 教授 (80094431)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 脳・神経 / 高血圧 / バイオマーカー / 電解質代謝 / ジギタリス |
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| Research Abstract |
Among a variety of endogenous digitalis, bufadienolides originally found in toads and now determined in humans were demonstrated to have their toxin types with biological functions. They increase with sodium-loading. Immortalized cell lines originated from adrenal-cortex and -medulla, and hypothalamic neurons were used to determine the origin and secretory mechanism of those bufadienolides and ouabain, and the active production was found. Collectively with our previous studies, I conclude that sodium metabolism is crucially involved in the pathogenesis of all types of hypertension ; thereby, brain renin-angiotensin-aldosterone system and ouabain are essentially implicated as players.
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Research Products
(15 results)
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[Journal Article] Ca^<2+> Entry Mode of Na^+/Ca^<2+> Exchanger as A New Therapeutic Target for Heart Failure with Preserved Ejection Fraction.2011
Author(s)
Kamimura D, Ohtani T, Sakata Y, Mano T, Takeda Y, Tamaki S, Omori Y, Tsukamoto Y, Furutani K, Komiyama Y, Yoshika M, Takahashi H, Matsuda T, Baba A, Umemura S, Miwa T, Komuro I, Yamamoto K
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Journal Title
Eur Heart J. (Epub ahead of print)
Peer Reviewed
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