2010 Fiscal Year Final Research Report
Elucidation of the molecular mechanism leading to the dysplasia of blood cells in the myelodysplastic syndromes
| Project/Area Number |
20590591
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
TOHYAMA Kaoru Kawasaki Medical School, 医学部, 教授 (80227561)
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| Co-Investigator(Kenkyū-buntansha) |
TASAKA Taizo 川崎医科大学, 医学部, 講師 (80343309)
TSUJIOKA Takayuki 川崎医科大学, 医学部, 講師 (50330551)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 血液学 / 遺伝子 / マイクロアレイ / プロテオーム / 細胞分化 |
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| Research Abstract |
Aiming at the elucidation of the molecular mechanism leading to the dysplasia of blood cells in the myelodysplastic syndromes, we studied the effect of lenalidomide on MDS-L cell line which shows a deletion of chromosome 5q. As a result, MDS-L cells revealed an inhibition of cytokinesis and a reduction of gene expression of cell cycle-related genes including KIF20A which was located at chromosome 5q. RNA interference study suggested that inhibition of KIF20A expression affects the growth and morphology of blood cells.
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[Journal Article] Prognostic significance of WT1 mRNA and anti-WT1 antibody levels in peripheral blood in patients with myelodysplastic syndromes.2010
Author(s)
Tamura H, Dan K, Yokose N, Iwakiri R, Ohta M, Sakamaki H, Tohyama K, Kondo A, Hyodo H, Nakamura K, Yamashita T, Elisseeva OA, Oka Y, Oji Y, Sugiyama H, Ogata K
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Journal Title
Leukemia Research 34
Pages: 986-990
Peer Reviewed
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[Journal Article] Lenalidomide is active in Japanese patients with symptomatic anemia in low- or intermediate-1 risk myelodysplastic syndromes (MDS) with a deletion 5q abnormality.2009
Author(s)
Harada H, Watanabe M, Suzuki K, Yanagita S, Suzuki T, Yoshida Y, Kimura A, Tsudo M, Matsuda A, Tohyama K, Taniwaki M, Takeshita K, Takatoku M, Ozawa K
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Journal Title
International Journal of Hematology 90
Pages: 353-360
Peer Reviewed
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[Journal Article] Myelodysplastic syndrome (MDS) with chromosome 5 abnormalities : a nation-wide survey in Japan.2008
Author(s)
Tasaka T, Tohyama K, Kishimoto M, Ohyashiki K, Mitani K, Hotta T, Kanamaru A, Okamoto S, Karasawa M, Kimura A, Tomonaga M, Uchiyama T, Ozawa K
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Journal Title
Leukemia 22
Pages: 1874-1881
Peer Reviewed
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[Journal Article] High-resolution whole genome tiling path array CGH analysis of CD34^+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival.2008
Author(s)
Starczynowski DT, Vercauteren S, Telenius A, Sung S, Tohyama K, Brooks-Wilson A, Spinelli JJ, Eaves CJ, Eaves AC, Horsman DE, Lam WL, Karsan A
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Journal Title
Blood 112
Pages: 3412-3424
Peer Reviewed
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