2010 Fiscal Year Final Research Report
A new diagnostic approach of Alzheimer's Disease based on the conformational changes of Aβ in serum
| Project/Area Number |
20590592
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
MATSUNAGA Yoichi Tokushima Bunri University, 薬学部, 教授 (80239053)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Tatsuo 福岡大学, 医学部, 教授
SUENAGA Midori 徳島文理大学, 薬学部, 助教
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| Project Period (FY) |
2008 – 2010
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| Keywords | アルツハイマー病 / アミロイド蛋白 / 加温 / 蛋白立体構造変化 / 血清診断 |
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| Research Abstract |
We clarified the conformational changes of amyloid protein in serum between from normal and Alzheimer's patients to the temperature within physiological limits. The former exhibited the sensitivity to temperature and the latter did not exhibit the sensitivity to temperature. The present study suggest a new approach to the diagnostics of Alzheimer's disease with serum.
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[Journal Article] Alcohol drinking and risk of Parkinson's disease : a case-control study in Japan.2010
Author(s)
W.Fukushima, Y.Miyake, K.Tanaka, S.Sasaki, C.Kiyohara, Y.Tsuboi, T.Yamada, T.Oeda, T.Miki, N.Kawamura, N.Sakae, H.Fukuyama, Y.Hirota, M.Nagai, the Fukuoka Kinki Parkinson's Disease Study Group
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Journal Title
BMC Neurology 10
Pages: 111
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[Journal Article] Active and passive smoking and risk of Parkinson's disease.2010
Author(s)
K.Tanaka, Y.Miyake, W.Fukushima, S.Sasaki, C.Kiyohara, Y.Tsuboi, T.Yamada, T.Oeda, T.Miki, N.Kawamura, N.Sakae, H.Fukuyama, Y.Hirota, M.Nagai, the Fukuoka Kinki Parkinson's Disease Study Group
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Journal Title
Acta.Neurol.Scand. 122
Pages: 377-382
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[Journal Article] Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson's disease : a case-control study in Japan.2010
Author(s)
K.Murakami, Y.Miyake, S.Sasaki, K.Tanaka, W.Fukushima, C.Kiyohara, Y.Tsuboi, T.Yamada, T.Oeda, T.Miki, N.Kawamura, N.Sakae, H.Fukuyama, Y.Hirota, M.Nagai, Fukuoka Kinki Parkinson's disease Study Group
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Journal Title
Br.J.Nutr 104
Pages: 757-764
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[Journal Article] Case-control study of risk of Parkinson's disease in relation to hypertension, hypercholesterolemia, and diabetes in Japan.2010
Author(s)
Y.Miyake, T.Tanaka, W.Fukushima, S. Sasaki, C.Kiyohara, Y.Tsuboi, T.Yamada, T.Oeda, T.Miki, N.Kawamura, N.Sakae, H. Fukuyama, Y.Hirota, M.Nagai, the Fukuoka Kinki Parkinson's Disease Study Group
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Journal Title
J Neurol Sci. 293
Pages: 82-86
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[Remarks] ホームページ等
