2010 Fiscal Year Final Research Report
Blood Levels of n-3 Fatty Acids and the Risk of stroke and Coronary Heart Disease Among Japanese The Japan Public Health Center-Based(JPHC) Study
| Project/Area Number |
20590638
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IWASAKI Motoki 国立癌センター, がん予防検診研究センター, 室長 (60392338)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 虚血性心疾患 / 脳卒中 / n-3系多価不飽和脂肪酸 / JPHC |
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| Research Abstract |
In Japan there have been a few epidemiological studies in which fish consumption(and n-3 fatty acid intake) and morbidity and/or mortality of coronary disease were studied. The results of those studies are not consistent. Some showed beneficial effects of fish, but others did not. In Japan, no there are no large-scale epidemiological studies on the relationship between blood fatty acid composition and the risk of cardiovascular death. We, therefore, conducted a nested case-control study with 209 coronary deaths and their controls(n=418) from the Japan Public Health Center-Based Study. The fatty acid composition of the total phospholipid fraction was measured by gas-chromatography. We found no significant difference in any fatty acid level. If both men and women are combined, there appears to be little influence of blood fatty acid composition on cardiovascular deaths.
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