The significance of oxidative stress-related markers in health education classes for lifestyle diseases

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590645
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Jichi Medical University
• Principal Investigator: KOTANI Kazuhiko Jichi Medical University, 医学部, 講師 (60335510)
• Project Period (FY): 2008 – 2010
• Keywords: 健康科学 / 健康教育 / 肥満 / 酸化ストレス / 代謝 / 酸化ストレスマーカー / 酸化LDL

Research Abstract

A weight reduction education on individuals with metabolic syndrome or a smoking cessation intervention on smokers suggested that the diacron reactive oxygen metabolites, an oxidative status marker, could reflect the upstream pathophysiology of the development of metabolic syndrome-related complications or smoking-induced disorders. Several intervention studies indicated that the oxidized low-density lipoprotein-related markers could provide more sensitive and comprehensive information regarding the association between lifestyles and atherogenic conditions when compared to general lipids markers. These measurements may lead to an open field for further investigation to improve health education classes for lifestyle diseases.

Research Products

• [Journal Article] The association between circulating secreted protein acidic and rich in cysteine (SPARC) and glycosylated haemoglobin during lifestyle-modified weight reduction intervention in obese male subjects. (2011)
  • Author(s): Kotani K, Yamada T, Taniguchi N.
  • Journal Title: J Int Med Res. 39(2) Pages: 528-532
  • Peer Reviewed
• [Journal Article] The relationship between urinary 8-hydroxydeoxyguanosine and metabolic risk factors in asymptomatic subjects. (2011)
  • Author(s): Miyamoto M, Kotani K, Ishibashi S, Taniguchi N.
  • Journal Title: Med Princ Pract. 20(2) Pages: 187-190
  • Peer Reviewed
• [Journal Article] The potential of serum amyloid A-LDL as a novel biomarker for cardiovascular disease risk. (2010)
  • Author(s): Kotani K, Satoh N, Yamada T, Gugliucci A.
  • Journal Title: Clin Lipid. 5(4) Pages: 489-495
  • Peer Reviewed
• [Journal Article] The association between adiponectin, HDL-cholesterol and α1-antitrypsin-LDL in female subjects without metabolic syndrome. (2010)
  • Author(s): Kotani K, Yamada T, Taniguchi N.
  • Journal Title: Lipids Health Dis. 9(1) Pages: 147
  • Peer Reviewed
• [Journal Article] The relationship between serum C-reactive protein and daily physical activity in Japanese hypertensive patients. (2010)
  • Author(s): Uurtuya S, Kotani K, Koibuchi H, Miyamoto M, Kario K, Yamada T, Taniguchi N.
  • Journal Title: Clin Exp Hypertens. 32(8) Pages: 517-522
  • Peer Reviewed
• [Journal Article] The influence of metabolic syndrome and chronic kidney disease on hemorheology assessed by the microchannel method. (2010)
  • Author(s): Kotani K, Satoh N, Yamada K, Taniguchi N, Shimatsu A.
  • Journal Title: J Physiol Anthropol. 29(5) Pages: 157-160
  • Peer Reviewed
• [Journal Article] Relationship between reactive oxygen metabolites and carotid intima-media thickness in subjects with hypercholesterolemia. (2010)
  • Author(s): Kotani K, Koibuchi H, Miyamoto M, Yamada T, Taniguchi N.
  • Journal Title: Med Princ Pract. 19(6) Pages: 496-498
  • Peer Reviewed
• [Journal Article] The association between blood glucose and oxidized lipoprotein(a) in healthy young women. (2010)
  • Author(s): Kotani K, Yamada S, Uurtuya S, Yamada T, Taniguchi N, Sakurabayashi I.
  • Journal Title: Lipids Health Dis. 9 Pages: 103
  • Peer Reviewed
• [Journal Article] Serum aspirin esterase is strongly associated with glucose and lipids in healthy subjects : different association patterns in subjects with type 2 diabetes mellitus. (2010)
  • Author(s): Kotani K, Kimura S, Ebara T, Caccavello R, Gugliucci A.
  • Journal Title: Diabetol Metab Syndr. 2 Pages: 50
  • Peer Reviewed
• [Journal Article] Serum cholesterol concentration associated with aspirin esterase activity in older people : preliminary data. (2010)
  • Author(s): Kotani K, Caccavello R, Hermo R, Yamada T, Taniguchi N, Gugliucci A.
  • Journal Title: Int J Med Sci. 7(2) Pages: 90-93
  • Peer Reviewed
• [Journal Article] The association between resistin, high-density lipoprotein cholesterol and carotid atherosclerosis in elderly women with hypertension. (2010)
  • Author(s): Kotani K, Adachi S, Tsuzaki K, Sakane N, Gugliucci A.
  • Journal Title: Int J Cardiol. 141(2) Pages: 193-194
  • Peer Reviewed
• [Journal Article] Changes on the physiological lactonase activity of serum paraoxonase 1 by a diet intervention for weight loss in healthy overweight and obese women. (2009)
  • Author(s): Kotani K, Sakane N, Sano Y, Tsuzaki K, Matsuoka Y, Egawa K, Yoshimura M, Horikawa C, Kitagawa Y, Kiso Y, Kimura S, Schulze J, Taing J, Gugliucci A.
  • Journal Title: J Clin Biochem Nutr. 45(3) Pages: 329-334
  • Peer Reviewed
• [Journal Article] Adiponectin gene single-nucleotide polymorphisms and treatment response to obesity. (2009)
  • Author(s): Tsuzaki K, Kotani K, Nagai N, Saiga K, Sano Y, Hamada T, Moritani T, Yoshimura M, Egawa K, Horikawa C, Kitagawa Y, Kiso Y, Sakane N.
  • Journal Title: J Endocrinol Invest. 32(5) Pages: 395-400
  • Peer Reviewed
• [Journal Article] The effects of lifestyle modification on a new oxidized low-density lipoprotein marker, serum amyloid A-LDL, in subjects with primary lipid disorder. (2009)
  • Author(s): Kotani K, Koibuchi H, Yamada T, Taniguchi N.
  • Journal Title: Clin Chim Acta. 409(1-2) Pages: 67-69
  • Peer Reviewed
• [Journal Article] Serum amyloid A protein and carotid intima-media thickness in healthy young subjects. (2009)
  • Author(s): Uurtuya S, Kotani K, Koibuchi H, Taniguchi N, Yamada T.
  • Journal Title: J Atheroscler Thromb. 16(3) Pages: 299-300
  • Peer Reviewed
• [Journal Article] Short-term low calorie diet intervention reduces serum advanced glycation end products in healthy overweight or obese adults. (2009)
  • Author(s): Gugliucci A, Kotani K, Taing J, Matsuoka Y, Sano Y, Yoshimura M, Egawa K, Horikawa C, Kitagawa Y, Kiso Y, Kimura S, Sakane N.
  • Journal Title: Ann Nutr Metab. 54(3) Pages: 197-201
  • Peer Reviewed
• [Journal Article] Thermoregulatory sympathetic nervous system activity and diet-induced waist-circumference reduction in obese Japanese women. (2009)
  • Author(s): Fujibayashi M, Hamada T, Matsumoto T, Kiyohara N, Tanaka S, Kotani K, Egawa K, Kitagawa Y, Kiso Y, Sakane N, Moritani T.
  • Journal Title: Am J Hum Biol. 21(6) Pages: 828-835
  • Peer Reviewed
• [Journal Article] A novel oxidized low-density lipoprotein marker, serum amyloid A-LDL, is associated with obesity and the metabolic syndrome. (2009)
  • Author(s): Kotani K, Satoh N, Kato Y, Araki R, Koyama K, Okajima T, Tanabe M, Oishi M, Yamakage H, Yamada K, Hattori M, Shimatsu A.
  • Journal Title: Atherosclerosis. 204(2) Pages: 526-531
  • Peer Reviewed
• [Presentation] The effects of lifestyle modification treatment on the serum oxidized lipoprotein(a) levels in obese women : a comparison with native lipoprotein(a). (2010)
  • Author(s): Kotani K, Yamada S, Yamada T, Taniguchi N, Sakurabayashi I
  • Organizer: 2010 Annual meeting of the American Association for Clinical Chemistry.
  • Place of Presentation: Anaheim, USA
  • Year and Date: 20100700
• [Presentation] 一般住民に対する運動および食事介入前後の体重,腹囲,BMI,体脂肪率の変化 (2009)
  • Author(s): 上原里程, 山縣千開, 福原円, 定金敦子, 青山泰子, 小谷和彦, 高村寿子, 中村好一
  • Organizer: 第68回日本公衆衛生学会総会
  • Place of Presentation: 奈良
  • Year and Date: 20091000
• [Presentation] 地域の健康教室における脂質に特化した検査の有用性と今後の課題 (2009)
  • Author(s): 津崎こころ, 小谷和彦, 山田俊幸
  • Organizer: 第60回日本電気泳動学会総会
  • Place of Presentation: 長野
  • Year and Date: 20090900
• [Presentation] 肥満に対する健康教室の経験 (2009)
  • Author(s): 懸樋英一, 小谷和彦
  • Organizer: 第32回日本プライマリ・ケア学会学術会議
  • Place of Presentation: 京都
  • Year and Date: 20090800
• [Presentation] Effect of lifestyle modifications on a new oxidized low-density lipoprotein marker, serum amyloid A-LDL, in asymptomatic subjects with primary dyslipidemia. (2009)
  • Author(s): Kotani K, Yamada T, Taniguchi N, Kawano M, Sakurabayashi I
  • Organizer: 2009 Annual meeting of the American Association for Clinical Chemistry (AACC).
  • Place of Presentation: Chicago, USA
  • Year and Date: 20090700
• [Remarks] ホームページ等なし