2010 Fiscal Year Final Research Report

The impact of plasma homocysteine and B complex vitamins on subclinical atherosclerosis amongst community-dwelling American and Japanese men

Research Project

Project/Area Number	20590670
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Public health/Health science
Research Institution	National Cardiovascular Center Research Institute
Principal Investigator	OKAMURA Tomonori National Cardiovascular Center Research Institute, 医学部, 教授 (00324567)
Co-Investigator(Renkei-kenkyūsha)	UESHIMA Hirotsugu 滋賀医科大学, 医学部, 特任教授 (70144483) KADOWAKI Takashi 滋賀医科大学, 医学部, 客員助教 (30324578)
Project Period (FY)	2008 – 2010
Keywords	ホモシステイン / 葉酸 / 冠動脈石灰化 / 内膜中膜複合体 / 日米比較
Research Abstract	Randomly selected community-based populations of 287 Japanese and 296 US men aged 40-49 were examined for intima-media thickness (IMT) of common carotid artery and coronary calcium in a previous survey. We measured plasma homocysteine and serum folate levels by stored blood sample. Plasma homocysteine levels are much lower in US participants than Japanese participants irrespective of more unfavorable subclinical atherosclerotic findings. Furthermore, we are not able to observe any relationship between plasma homocysteine or serum folate levels and above-mentioned subclinical atherosclerotic findings in both populations.

(5 results)