2010 Fiscal Year Final Research Report
Mutational analysis of the mitochondrial DNA detected in sudden cardiac death caused by cardiomyopathy
| Project/Area Number |
20590685
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Kitasato University |
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Principal Investigator |
NAKAMURA Shigeki Kitasato University, 医学部, 講師 (70130268)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Chikako 北里大学, 医学部, 助教 (30433717)
FURUKAWA Masataka 北里大学, 医学部, 講師 (90051911)
KURIHARA Katsuyoshi 北里大学, 医学部, 教授 (90138123)
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| Research Collaborator |
IRIE Wataru 北里大学, 医学部, 特任助教 (80597352)
KOBAYASHI Masamune 北里大学, 大学院・医療系研究科, 博士課程法医学専攻
MAEDA Kazuho 北里大学, 大学院・医療系研究科, 博士課程法医学専攻
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| Project Period (FY) |
2008 – 2010
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| Keywords | 心筋症 / 拡張型心筋症 / 肥大型心筋症 / ミトコンドリアDNA / ハプログループ / 心臓性突然死 / 遺伝子診断 / 遺伝子解析 |
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| Research Abstract |
Comprehensive screening of Mitochondrial DNA (mtDNA) was performed in consented autopsy cases diagnosed as cardiomyopathies (CMs), in order to evaluate the prevalence of gene mutations in sudden cardiac death caused by CMs. Our result suggested that missense mutations were detected in 42% of DCM cases and in 20% of HCM cases. It was indicated that genetic analysis of mtDNA was useful to decide diagnosis of CM for forensic autopsy cases.
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