Role of Food Intolerance and Protease on Pathophysiology of Irritable Bowel Syndrome

2011 Fiscal Year Final Research Report

• Project/Area Number: 20590693
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Tohoku University
• Principal Investigator: KANAZAWA Motoyori 東北大学, 大学院・医学系研究科, 講師 (70323003)
• Co-Investigator(Kenkyū-buntansha): FUKUDO Shin 東北大学, 大学院・医学系研究科, 教授 (80199249) ; WATANABE Satoshi 東北大学, 大学院・医学系研究科, 非常勤講師 (40431506)
• Co-Investigator(Renkei-kenkyūsha): KANO Michiko 東北大学, 大学院・医学系研究科, 助教 (20344658)
• Project Period (FY): 2008 – 2011
• Keywords: 過敏性腸症候群 / 炎症免疫 / 内臓知覚 / 大腸運動

Research Abstract

Our aims were to determine whether camostat mesilate (600mg/day), a synthetic protease inhibitor, changes visceral pain sensitivity and gastrointestinal motility and whether these changes affect clinical symptom severity in patients with irritable bowel syndrome (IBS). As a result, camostat mesilate has no effect on visceral sensitivity, colonic motility or serum cytokines compared with placebo in IBS patients.

Research Products

• [Journal Article] Effect of 5-HT(4)receptor agonist mosapride citrate on rectosigmoid sensorimotor function in patients with irritable bowel syndrome (2011)
  • Author(s): Kanazawa M, Watanabe S, Tana C, Komuro H, Aoki M, Fukudo S.
  • Journal Title: Neurogastroenterol Motil Volume: 23 Pages: 754-759
  • DOI: DOI:10.1111/j.1365-2982.2011.01732.x
  • Peer Reviewed
• [Journal Article] Lifestyle and psychological factors related to irritable bowel syndrome in nursing and medical school students (2011)
  • Author(s): Okami Y, Kato T, Nin G, Harada K, Aoi W, Wada S, Higashi A, Okuyama S, Ichikawa H, Kanazawa M, Fukudo S.
  • Journal Title: J Gastrointestinal Volume: 46 Pages: 1403-1410
  • DOI: DOI:10.1007/s00535-011-0454-2
  • Peer Reviewed
• [Journal Article] Effect of repetitive transcranial magnetic stimulation on rectal function and emo tion in humans (2011)
  • Author(s): Aizawa Y, Morishita J, Kano M, Mori T, Izumi SI, Tsutsui K, Iijima T, Kanazawa M, Fukudo S.
  • Journal Title: J Gastroenterol Volume: 46 Pages: 1171-1180
  • DOI: DOI:10.1007/s00535-011-0423-9
  • Peer Reviewed
• [Journal Article] Effect of rikkunshito on gastric sensorimotor function under distention (2011)
  • Author(s): Shiratori M, Shoji T, Kanazawa M, Hongo M, Fukudo S.
  • Journal Title: Neurogastroenterol Motil Volume: 23 Pages: 323-9
  • DOI: DOI:10.1111/j.1365-2982.2010.01648.x
  • Peer Reviewed
• [Journal Article] Visceral hypersensitivity in irritable bowel syndrome (2011)
  • Author(s): Kanazawa M, Hongo M, Fukudo S.
  • Journal Title: J Gastroenterol Hepatol Volume: 26Suppl 3 Pages: 119-21
  • DOI: DOI:10.1111/j.1440-1746.2011.06640.x
  • Peer Reviewed
• [Journal Article] Gene environment, and brain-gut interactions in irritable bowel syndrome (2011)
  • Author(s): Fukudo S, Kanazawa M.
  • Journal Title: J Gastroenterol Hepatol Volume: 26Suppl 3 Pages: 110-5
  • DOI: DOI:10.1111/j.1440-1746.2011.06631.x
  • Peer Reviewed
• [Journal Article] Biopsychosocial model of irritable bowel syndrome (2011)
  • Author(s): Tanaka Y, Kanazawa M, Fukudo S, Drossman DA.
  • Journal Title: J Neurogastroenterol Motil Volume: 17 Pages: 131-9
  • DOI: DOI:10.5056/jnm.2011.17.2.131
  • Peer Reviewed
• [Journal Article] Effect of autogenic training on general improvement in patients with irritable bowel syndrome : a randomized controlled trial (2010)
  • Author(s): Shinozaki M, Kanazawa M, Kano M, Endo Y, Nakaya N, Hongo M, Fukudo S.
  • Journal Title: Appl Psychophysiol Biofeedback Volume: 35 Pages: 189-198
  • DOI: DOI:10.1007/s10484-009-9125-y
  • Peer Reviewed
• [Journal Article] Site-specific differences in central processing of visceral stimuli from the rectum and the descending colon in men (2010)
  • Author(s): Kanazawa M, Hamaguchi T, Watanabe S, Terui T, Mine H, Kano M, Fukudo S.
  • Journal Title: Neurogastroenterol Motil Volume: 22 Pages: 173-180
  • DOI: DOI:10.1111/j.1365-2982.2009.01417.x
  • Peer Reviewed
• [Journal Article] Role of microbial fermentation products in irritable bowel syndrome (2010)
  • Author(s): Fukudo S, Umesaki Y, Imaoka A, Tana C, Handa T, Kanazawa M.
  • Journal Title: Neurogastroenterol Motil Volume: 22 Pages: 1148
  • DOI: DOI:10.1111/j.1365-2982.2010.01570.x
  • Peer Reviewed
• [Journal Article] Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome (2010)
  • Author(s): Tana C, Umesaki Y, Imaoka A, Handa T, Kanazawa M, Fukudo S.
  • Journal Title: Neur ogastroenterol Motil Volume: 22 Pages: 512-519
  • DOI: DOI:10.1111/j.1365-2982.2010.01570.x
  • Peer Reviewed
• [Journal Article] Differential responding of autonomic function to histamine H antagonism in irritable bowel syndrome (2010)
  • Author(s): Hattori T, Watanabe S, Kano M, Kanazawa M, Fukudo S.
  • Journal Title: Neurogastroenterol Motil Volume: 22 Pages: 1284-1291
  • DOI: DOI:10.1111/j.1365-2982.2010.01568.x
  • Peer Reviewed
• [Journal Article] Impact of serotonin transporter gene polymorphism on brain activation by colorectal distention (2009)
  • Author(s): Fukudo S, Kanazawa M, Mizuno T, Hamaguchi T, Kano M, Watanabe S, Sagami Y, Shoji T, Endo Y, Hongo M, Itoyama Y, Yanai K, Tashiro M, Aoki M.
  • Journal Title: Neuroimage Volume: 47 Pages: 946-51
  • DOI: DOI:10.1016/j. neuroimage.2009.04.083
  • Peer Reviewed
• [Journal Article] Brain activation covari ated with changes in heart rate, heart rate variability and plasma catecholamines during rectal distention (2009)
  • Author(s): Suzuki H, Watanabe S, Hamaguchi T, Mine H, Terui T, Kanazawa M, Oohisa N, Maruyama M, Yambe T, Itoh M, Fukudo S.
  • Journal Title: Psychosom Med Volume: 71 Pages: 619-626
  • DOI: DOI:10.1097/PSY. 0b013e31819b69ca
  • Peer Reviewed
• [Journal Article] Contributions of pain sensitivity and colonic motility to IBS symptom severity and predominant bowel habits (2008)
  • Author(s): Kanazawa M, Palsson OS, Thiwan SI, Turner MJ, van Tilburg MA, Gangarosa LM, Chitkara DK, Fukudo S, Drossman DA, Whitehead WE.
  • Journal Title: Am J Gastroenterol Volume: 103 Pages: 2550-2561
  • DOI: DOI:10.1111/j.1572-0241.2008.02066.x
  • Peer Reviewed
• [Journal Article] Changes in salivary physiological stress markers induced by muscle stretching in patients with irritable bowel syndrome (2008)
  • Author(s): Hamaguchi T, Fukudo S, Kanazawa M, Tomiie T, Shimizu K, Oyama M, Sakurai K.
  • Journal Title: Biopsychosoc Med Volume: 2 Pages: 20
  • DOI: DOI:10.1186/1751-0759-2-20
  • Peer Reviewed
• [Journal Article] Small intestinal bacterial overgrowth in irritable bowel syndrome : Association with colon motility, bowel symptoms, and psychological distress (2008)
  • Author(s): Grover M, Kanazawa M, Chitkara DK, Gangarosa LM, Palsson OS, Drossman DA, Turner MJ, Whitehead WE.
  • Journal Title: Neurogastroenterol Motil Volume: 20 Pages: 998-1008
  • DOI: DOI:10.1111/j.1365-2982.2008.01142.x
  • Peer Reviewed
• [Presentation] Increased stomach aches in children are associated with parent IBS status and maladaptive parenting in Japan (2011)
  • Author(s): Kanazawa M, Whitehead WE, Levy, RL Seino S, Tatsuta N, Palsson OS, Turner MJ, Endo Y, Nakai K, Satoh H, Fukudo S.
  • Organizer: The 112th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-05-08
• [Presentation] Visceral Hypersensitivity in Irritable Bowel Syndrome (2010)
  • Author(s): Kanazawa M, Hongo M, Fukudo S.
  • Organizer: The 1st Asian Pacific Topic Conference (APTC2010)
  • Place of Presentation: Tokyo
  • Year and Date: 2010-11-27
• [Presentation] Motility response to colonic distention is increased in post-infectious irritable bowel syndrome (PI-IBS) (2010)
  • Author(s): Kanazawa M, Palsson OS, Van Tilburg MA, Gangarosa LM, Fukudo S, Drossman DA, Whitehead WE.
  • Organizer: The 111th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-01
• [Presentation] High-sensitive C-reactive protein may be one of blood biomarkers for visceral hypersensitivity in irritable bowel syndrome (IBS) (2009)
  • Author(s): Kanazawa M, Tana C, Watanabe S, Palsson OS, Whitehead WE, Fukudo S.
  • Organizer: The 110th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-05-30
• [Presentation] A history of sexual abuse and catastrophizing have an impact on IBS symptom severity that is unrelated to psychological distress (2009)
  • Author(s): Kanazawa M, Palsson OS, Van Tilburg MA, Turner MJ, Thiwan SIM, Gangarosa LM, Fukudo S, Drossman DA, Whitehead WE.
  • Organizer: The 110th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-05-30
• [Presentation] Psychological distress and reassurance from physicians may affect reporting satisfactory relief in patients with irritable bowel syndrome (2008)
  • Author(s): Kanazawa M, Palsson OS, Shinozaki M, Endo Y, Sagami Y, Shoji T, Hongo M, Fukudo S, Whitehead WE.
  • Organizer: 10th International Congress of Behavioral
  • Place of Presentation: Medicine, Tokyo
  • Year and Date: 2008-08-30
• [Book] Pathophysiology of irritable bowel syndrome with diarrhea (2010)
  • Author(s): Kanazawa M, Fukudo S.
  • Total Pages: 209-214
  • Publisher: Nova Science Publishers Hauppauge NY
• [Book] Is colonic hypersensitivity really a biological marker of irritable bowel syndrome (IBS)? (2009)
  • Author(s): Kanazawa M, Fukudo S.
  • Total Pages: 155-162
  • Publisher: Nova Science Publishers, Hauppauge NY