2010 Fiscal Year Final Research Report
A study for an essential metabolic shift in glycolytic pathway observed during the transition from cellular senescence to carcinogenesis
| Project/Area Number |
20590696
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General internal medicine (including Psychosomatic medicine)
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
KONDOH Hiroshi Kyoto University, 医学研究科, 助教 (80402890)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YOKODE Masayuki 京都大学, 医学研究科, 教授 (20252447)
MARUYAMA Takeshi 京都大学, 医学研究科, 研究員 (70467463)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 細胞老化 / 癌化 / 解糖系代謝 |
|---|
| Research Abstract |
Stress-induced senescence is recently thought to be a barrier against carcinogensis. We previously cloned the phosphoglycerate mutase (PGM) cDNA as senescence bypassing clone. We addressed the question why and how enhanced glycolysis could affect cellular senescence. We planned to clarify the molecular mechanism of regulation and physiological impact of PGM. During these attempt, we cloned a PGM binding protein as a novel ubiquitin ligase, called UBLX1. Also we established PGM transgenic mice model.
|
