2010 Fiscal Year Final Research Report
ACTION MECHANISM OF A KAMPO MEDICINE "MAOTO" AGAINST INFLUENZA VIRUS INFECTION
Project/Area Number |
20590705
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General internal medicine (including Psychosomatic medicine)
|
Research Institution | Kitasato University |
Principal Investigator |
NAGAI Takayuki Kitasato University, 大学院・感染制御科学府, 講師 (00172487)
|
Co-Investigator(Kenkyū-buntansha) |
KIYOHARA Hiroaki 北里大学, 大学院・感染制御科学府, 准教授 (70161601)
|
Co-Investigator(Renkei-kenkyūsha) |
ODAGUCHI Hiroshi 北里大学, 東洋医学総合研究所, 室長 (40214150)
|
Project Period (FY) |
2008 – 2010
|
Keywords | 漢方薬 / 麻黄湯 / インフルエンザ / 解熱作用 / 自然抗体 / 東洋医学 |
Research Abstract |
Oral administration of a Kampo medicine "maoto" showed antipyretic activity, and reduced influenza virus (IFV) titers in nasal wash and broncho- alveolar lavage fluid (BALF) of mice at 2 days post infection. Maoto increased anti-IFV antibody titers in nasal wash, BALF and serum at 2 days post infection. Maoto also increased IFV-bound antibody titer in BALF and serum of uninfected mice. These results suggest that maoto shows anti-IFV activity through the increment of natural antibody.
|
Research Products
(26 results)